2-GUANIDINOBENZIMIDAZOLE
- CAS NO.:5418-95-1
- Empirical Formula: C8H9N5
- Molecular Weight: 175.19
- MDL number: MFCD00005590
- EINECS: 226-527-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:39
What is 2-GUANIDINOBENZIMIDAZOLE?
Description
2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1?2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3? Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4
Chemical properties
BROWN-PURPLE FINE CRYSTALLINE POWDER
The Uses of 2-GUANIDINOBENZIMIDAZOLE
N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics.
Definition
ChEBI: 2-Benzimidazolylguanidine is an aminoimidazole.
References
1) Hong?et al. (2015),?Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep.,?5?14077 2) Hong?et al.?(2014),?Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA,?111?9971 3) Gianti?et al. (2016),?On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA,?113?E8359 4) Pupo and Gonzalez (2014),?In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA,?111?9673
Properties of 2-GUANIDINOBENZIMIDAZOLE
Melting point: | 242-244 °C (dec.) (lit.) |
Boiling point: | 296.48°C (rough estimate) |
Density | 1.2954 (rough estimate) |
refractive index | 1.6900 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming) |
form | solid |
pka | 13.67±0.30(Predicted) |
color | Beige |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
CAS DataBase Reference | 5418-95-1(CAS DataBase Reference) |
EPA Substance Registry System | Guanidine, 1H-benzimidazol-2-yl- (5418-95-1) |
Safety information for 2-GUANIDINOBENZIMIDAZOLE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-GUANIDINOBENZIMIDAZOLE
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