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HomeProduct name list2-GUANIDINOBENZIMIDAZOLE

2-GUANIDINOBENZIMIDAZOLE

  • CAS NO.:5418-95-1
  • Empirical Formula: C8H9N5
  • Molecular Weight: 175.19
  • MDL number: MFCD00005590
  • EINECS: 226-527-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:39
2-GUANIDINOBENZIMIDAZOLE Structural

What is 2-GUANIDINOBENZIMIDAZOLE?

Description

2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1?2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3? Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4

Chemical properties

BROWN-PURPLE FINE CRYSTALLINE POWDER

The Uses of 2-GUANIDINOBENZIMIDAZOLE

N-1H-Benzimidazol-2-ylguanidine is used as a reagent in the synthesis of novel fused pyrimidines and imidazoles as potential analgesics.

Definition

ChEBI: 2-Benzimidazolylguanidine is an aminoimidazole.

References

1) Hong?et al. (2015),?Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep.,?5?14077 2) Hong?et al.?(2014),?Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA,?111?9971 3) Gianti?et al. (2016),?On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA,?113?E8359 4) Pupo and Gonzalez (2014),?In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA,?111?9673

Properties of 2-GUANIDINOBENZIMIDAZOLE

Melting point: 242-244 °C (dec.) (lit.)
Boiling point: 296.48°C (rough estimate)
Density  1.2954 (rough estimate)
refractive index  1.6900 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Soluble in DMSO (up to 50 mg/ml) or in Water (up to 4 mg/ml with warming)
form  solid
pka 13.67±0.30(Predicted)
color  Beige
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference 5418-95-1(CAS DataBase Reference)
EPA Substance Registry System Guanidine, 1H-benzimidazol-2-yl- (5418-95-1)

Safety information for 2-GUANIDINOBENZIMIDAZOLE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-GUANIDINOBENZIMIDAZOLE

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