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HomeProduct name list2-Fluoro-5-nitrobenzoic acid

2-Fluoro-5-nitrobenzoic acid

  • CAS NO.:7304-32-7
  • Empirical Formula: C7H4FNO4
  • Molecular Weight: 185.11
  • MDL number: MFCD00134238
  • EINECS: 627-772-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-12-25 17:47:29
2-Fluoro-5-nitrobenzoic acid  Structural

What is 2-Fluoro-5-nitrobenzoic acid ?

Chemical properties

white to light yellow crystal powder

The Uses of 2-Fluoro-5-nitrobenzoic acid

2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of:

  • dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support
  • synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols
  • in the synthesis of oxazepines

The Uses of 2-Fluoro-5-nitrobenzoic acid

2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support, synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols, in the synthesis of oxazepines.

General Description

2-Fluoro-5-nitrobenzoic acid is reported to react with an aldehyde, isonitrile and a primary amine tethered to a Boc-protected internal amino or hydroxyl nucleophile, to afford the Ugi product.

Properties of 2-Fluoro-5-nitrobenzoic acid

Melting point: 142-144 °C (lit.)
Boiling point: 337.7±27.0 °C(Predicted)
Density  1.568±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Soluble in chloroform, ethanol.
form  Crystalline Powder
pka 2.54±0.10(Predicted)
color  White to pale yellow
BRN  1912835
CAS DataBase Reference 7304-32-7(CAS DataBase Reference)

Safety information for 2-Fluoro-5-nitrobenzoic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Fluoro-5-nitrobenzoic acid

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