2-Ethylhexyl-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate
- CAS NO.:947753-66-4
- Empirical Formula: C25H28NO3-
- Molecular Weight: 390.49472
- EINECS: 700-213-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:17
What is 2-Ethylhexyl-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate?
Absorption
Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . At this time, however, studies demonstrate that the components of most commonly used sunscreens are likely absorbed into the skin at least to some extent - although penetration to deeper tissues and the cutaneous circulation remains limited . Despite the extensive use of sunscreen products around the world, there have been few reports of adverse effects related to their use .
Toxicity
Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal. Additionally, no ocular irritation, phototoxicity, dermal irritation, or allergic contact sensitization has been reported to any significant degree .
The Uses of 2-Ethylhexyl-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate
Ethylhexyl Methoxycrylene is a useful research chemical compound used as a photostabalizer which acts by quenching the singlet excited state of UV filters.
Background
Ethylhexyl methoxycrylene is a photostabilizer that preserves the effectiveness of UV filters by interacting with both the singlet and triplet states . It returns UV filters to their ground states without absorbing sunlight . It is used as a solvent for crystalline UV filters and is easily emulsified and suitable for use in various lotions, creams, sprays, sticks, and gel formulations . It currently enjoys regional approvals in Canada, the EU, and the US .
Indications
Ethylhexyl methoxycrylene is employed as a photostabilizing agent in various sunscreen products .
Pharmacokinetics
As an active ingredient in topical sunscreen products, ethylhexyl methoxycrylene is applied directly onto human skin where it acts as a critical component for conferring photostability to the product's other constituent ingredients, protecting the product as a whole from deterioration in the sunlight . Additionally, considering the high log Pow value (6.05-6.32) and low water solubility, dermal absorption of ethylhexyl methoxycrylene is expected to be low. This is supported by a dermal absorption of less than 5% observed for an acceptable analogue of the notified chemical . Consequently, little systemic exposure and pharmacokinetics are expected and users can freely wash off and re-apply ethylhexyl methoxycrylene containing compounds as necessary.
Metabolism
Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin . The systemic presence of the compound is consequently expected to be minimal.
Properties of 2-Ethylhexyl-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate
Boiling point: | 391.85℃[at 101 325 Pa] |
Density | 1.08[at 20℃] |
vapor pressure | 0Pa at 25℃ |
Water Solubility | 40μg/L at 20℃ |
Safety information for 2-Ethylhexyl-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate
Computed Descriptors for 2-Ethylhexyl-2-cyano-3-(4-methoxyphenyl)-3-phenylprop-2-enoate
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