2-Ethyl-1-butanol

Description

Ethylbutanol is a colorless liquid with a mild,alcoholic odor. Molecular weight = 102.20; Boilingpoint = 149℃. Freezing/Melting point = -114℃; Vaporpressure = 0.89 mmHg at 20℃; Flash point = 58℃ (oc).Hazard Identification (based on NFPA-704 M RatingSystem): Health 1, Flammability 2, Reactivity 0. Slightlysoluble in water

Chemical properties

clear colorless to slightly yellowish liquid

Chemical properties

Ethylbutanol is a colorless liquid with a mild, alcoholic odor.

The Uses of 2-Ethyl-1-butanol

It is used as a perfuming agent in cosmetics industry. 2-Ethyl-1-butanol is used for the synthesis of various pharmaceutical compounds, such as novel branched Alkyl carbamates, acting as anticonvulsant agent. It is also a solvent used for various organic synthesis, separation processes and ionic liquids, and solvent mixtures for pharmaceutical applications . It is also used to make penetrating oils, corrosion inhibitors, plasticizers, and perfumes; as cleaning agent for printed circuits; and to improve flow of paints and varnishes.

The Uses of 2-Ethyl-1-butanol

Solvent for oils, resins, waxes, dyes; diluent; synthesis of perfumes, drugs; flavoring.

Production Methods

2-Ethylbutanol can be prepared commercially by the aldol condensation of acetaldehyde and 1-butanal and subsequent hydrogenation.

General Description

Flash point of 137°F. Less dense than water and slightly soluble in water. Vapors are heavier than air. Used as a solvent and in the manufacture of pharmaceuticals.

Air & Water Reactions

Flammable. Slightly soluble in water.

Reactivity Profile

Flammable and/or toxic gases are generated by the combination of alcohols, such as 2-ETHYL-1-BUTANOL, with alkali metals, nitrides, and strong reducing agents. Alcohols react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Hazard

Moderate fire risk.

Health Hazard

Liquid causes eye burns. Vapors may be mildly irritating to nose and throat.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Moderately toxic by ingestion and sktn contact. A skin and severe eye irritant. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use dry chemical, CO2, foam, fog. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALCOHOLS.

Potential Exposure

Used as a solvent; for making dyes, perfumes, flavorings, and drugs

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

Metabolism

Research reported that when 25 mmol (2.55 g) of 2-ethyl-1-butanol was administered by oral gavage to 3.0 kg rabbits (n = 3), 40% of the administered dose was excreted in the urine as the glucuronide within 24 h. Furthermore, Kamil et al. reported that 2-ethyl-1-butanol, 2.55 g (3.1 ml), administered by oral gavage to a rabbit, was excreted in the urine (24 h) as diethylacetylglucuronide. A small amount of methyl-n-propyl ketone was also excreted[1].

storage

Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with this chemical you should be trainedon its proper handling and storage. Store in tightly closedcontainers in a cool, well-ventilated area away from oxidizers, strong acids, strong bases, reducing agents, heat, andsources of ignition. Where possible, automatically pumpliquid from drums or other storage containers to processcontainers.

Shipping

UN2275 Ethylbutanol, Hazard Class: 3; Labels: 3-Flammable liquid

Purification Methods

Dry it with CaSO4 for several days, filter and fractionally distil it. [Beilstein 1 IV 1725.]

Incompatibilities

May form explosive mixture with air. Incompatible with oxidizers, strong acids; caustics, isocyanates, amines, isocyanates.

Waste Disposal

Incineration by spraying or in paper packaging. Flammable solvent may be added.

References

[1] D. McGinty, A.M. Api, C.S. Letizia. “Fragrance material review on 2-ethyl-1-butanol.” Food and Chemical Toxicology 48 (2010): Pages S85-S88.