2-Chloropyridine-5-boronic acid
Synonym(s):2-Chloro-5-pyridineboronic acid
- CAS NO.：444120-91-6
- Empirical Formula: C5H5BClNO2
- Molecular Weight: 157.36
- MDL number: MFCD03094998
- EINECS: 628-524-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 2-Chloropyridine-5-boronic acid?
Chemical properties
White to off-white solid
The Uses of 2-Chloropyridine-5-boronic acid
6-Chloro-3-pyridinylboronic acid can be used:
- To prepare biologically significant 3-arylcoumarins by reacting with 3-chlorocoumarin through Suzuki reaction.
- As a substrate in the synthesis of 11-(pyridinylphenyl)steroid with progesterone agonist/antagonist profile.
- As a substrate in the preparation of α- secondary and tertiary pyridines by the reaction of pyridotriazoles with boronic acids.
- As a substrate in the palladium-catalyzed α-arylation of saturated cyclic amines and N-methyl amines.
Properties of 2-Chloropyridine-5-boronic acid
| Melting point: | 165 °C(lit.) |
| Boiling point: | 336.9±52.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 6.70±0.10(Predicted) |
| color | White to Light yellow |
| BRN | 9119810 |
| CAS DataBase Reference | 444120-91-6(CAS DataBase Reference) |
Safety information for 2-Chloropyridine-5-boronic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Chloropyridine-5-boronic acid
| InChIKey | WPAPNCXMYWRTTL-UHFFFAOYSA-N |
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