2-chloro-3-fluoropyridin-4-aMine

CAS NO.：1227577-03-8
Empirical Formula: C5H4ClFN2
Molecular Weight: 146.55
MDL number: MFCD16606117
EINECS: 818-063-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-25 16:59:36

What is 2-chloro-3-fluoropyridin-4-aMine?

Synthesis

TFA (5 mL) was added to a solution of (2- chloro-3-fluoropyridin-4-yl)carbamic acid fert-butyl ester (1.9 g, 7.7 mmol) in DCM (10 mL). The solution was stirred at ambient temperature for 5 hours and concentrated under reduced pressure. The resultant residue was dissolved in DCM and purified by column chromatography on an NH2 cartridge (0-10 per cent MeOH in DCM) to afford 2-chloro-3-fluoropyridin-4-aMine as a beige solid (0.96 g, 94 per cent yield). NMR (400 MHz, CDC13): δ 7.82 (d, J = 5.4 Hz, 1H), 6.60 (t, J= 5.8 Hz, 1H), 4.38 (br s, 2H).

Properties of 2-chloro-3-fluoropyridin-4-aMine

Boiling point:	271.9±35.0 °C(Predicted)
Density	1.449±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	2.81±0.42(Predicted)
form	powder
color	Brown

Safety information for 2-chloro-3-fluoropyridin-4-aMine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.