2-Bromo-6-nitrophenol
- CAS NO.：13073-25-1
- Empirical Formula: C6H4BrNO3
- Molecular Weight: 218
- MDL number: MFCD02683216
- EINECS: 629-309-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is 2-Bromo-6-nitrophenol?
Chemical properties
White solid
The Uses of 2-Bromo-6-nitrophenol
2-Bromo-6-nitrophenol is an intermediate used in the synthesis of N-Hydroxy Eltrombopag (H825795), which is a derivative compound of Eltrombopag (508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
Preparation
2-Bromo-6-nitrophenol can be prepared by reacting ammonium formate with hydroxyl group of 2-bromo-6-nitropyridine. The reaction yield can be improved by activating the hydroxyl group and removing impurities through a dehydration reaction.
Synthesis
2-Bromo-6-nitrophenol is synthesized by coupling metal salts with nitro groups or amines, which are called Suzuki coupling reactions.
Properties of 2-Bromo-6-nitrophenol
| Melting point: | 66-70 °C (lit.) |
| Boiling point: | 227.2±20.0 °C(Predicted) |
| Density | 1.881±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform; Methanol |
| form | Solid |
| pka | 5.36±0.24(Predicted) |
| color | Yellow |
| CAS DataBase Reference | 13073-25-1(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Bromo-6-nitrophenol (13073-25-1) |
Safety information for 2-Bromo-6-nitrophenol
| Signal word | Warning |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P501:Dispose of contents/container to..… |
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