2-(Aminomethyl)-5-methylpyrazine

CAS NO.：132664-85-8
Empirical Formula: C6H9N3
Molecular Weight: 123.16
MDL number: MFCD01314542
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-30 09:26:46

What is 2-(Aminomethyl)-5-methylpyrazine ?

Description

2-(Aminomethyl)-5-methylpyrazine can be used as a pharmaceutical synthesis intermediate, for example, to prepare pyrocatecholamide, which is an antiplatelet drug with a dual inhibitory action. This substance can be prepared from 2,5-dimethylpyrazine as a reaction raw material.

Synthesis

2,5-dimethylpyrazine can be used as a reaction raw material to prepare the intermediate 2-chloromethyl-5-methylpyrazine. It can then be further reacted with sodium iodide and potassium phthalimide to prepare N-((5-methylpyrazine-2-yl)methyl)isoindole-1,3-dione. Finally, it can be reacted with hydrazine hydrate to prepare 2-(Aminomethyl)-5-methylpyrazine.

Properties of 2-(Aminomethyl)-5-methylpyrazine

Boiling point:	216.2±35.0 °C(Predicted)
Density	1.09
refractive index	1.5380-1.5430
storage temp.	Refrigerator
form	clear liquid
pka	6.94±0.29(Predicted)
Specific Gravity	1.09
color	Colorless to Yellow to Green
InChI	InChI=1S/C6H9N3/c1-5-3-9-6(2-7)4-8-5/h3-4H,2,7H2,1H3
CAS DataBase Reference	132664-85-8(CAS DataBase Reference)

Safety information for 2-(Aminomethyl)-5-methylpyrazine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to..…