2-amino-N-(2,2,2-trifluoroethyl)acetamide

CAS NO.：359821-38-8
Empirical Formula: C4H7F3N2O
Molecular Weight: 156.11
MDL number: MFCD09944516
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-16 09:25:11

What is 2-amino-N-(2,2,2-trifluoroethyl)acetamide?

The Uses of 2-amino-N-(2,2,2-trifluoroethyl)acetamide

2-amino-N-(2,2,2-trifluoroethyl) acetamide, which is usually stable in the form of salt, is a key intermediate in the synthesis of fluralaner, a new broad-spectrum veterinary insecticide.

Preparation

The method of preparing 2-amino-N-(2,2,2-trifluoroethyl) acetamide and its salt is to react the glycine protected by N-phthalyl group with trifluoroethylamine or its salt to form an amide, and remove the protective group under the action of hydrated fibril to obtain the crude product of 2- amino-N-(2,2,2-trifluoroethyl) acetamide.The crude product can be salted with acid to get a salt of 2-amino-N-(2,2, 2-trifluoroethyl) acetamide, and finally add a base to dissociate pure 2-amino-N-(2,2, 2-trifluoroethyl) ethylkuroamine.

Properties of 2-amino-N-(2,2,2-trifluoroethyl)acetamide

Boiling point:	227.5±40.0 °C(Predicted)
Density	1.294±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	12.87±0.46(Predicted)
color	Yellow

Safety information for 2-amino-N-(2,2,2-trifluoroethyl)acetamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area.