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HomeProduct name list2-Amino-4-nitrophenol

2-Amino-4-nitrophenol

Synonym(s):2-Hydroxy-5-nitroaniline

  • CAS NO.:99-57-0
  • Empirical Formula: C6H6N2O3
  • Molecular Weight: 154.12
  • MDL number: MFCD00007695
  • EINECS: 202-767-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:44
2-Amino-4-nitrophenol Structural

What is 2-Amino-4-nitrophenol?

Chemical properties

OCHRE CRYSTALLINE POWDER

The Uses of 2-Amino-4-nitrophenol

2-Amino-4-nitrophenol is used in preparing some mordant dyes and in some hair dyes.

The Uses of 2-Amino-4-nitrophenol

An aromatic constituent found in hair dyes and other cosmetic products with very low levels of mutagenic activity.

Definition

ChEBI: 2-Amino-4-nitrophenol is a member of 4-nitrophenols.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 82, 1955
The Journal of Organic Chemistry, 45, p. 4992, 1980 DOI: 10.1021/jo01312a039

General Description

Orange prisms or yellow powder. No odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Oxidation of 2-Amino-4-nitrophenol may occur in the presence of air and violent decomposition may occur if 2-Amino-4-nitrophenol is allowed to dry out completely at elevated temperatures. 2-Amino-4-nitrophenol is stable when stored protected from light and under nitrogen for two weeks at temperatures up to 140° F, and storage under nitrogen for up to 24 weeks at room temperature (77° F) should produce no loss of stability. 2-Amino-4-nitrophenol is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. 2-Amino-4-nitrophenol is also incompatible with iron.

Fire Hazard

Flash point data for 2-Amino-4-nitrophenol are not available. 2-Amino-4-nitrophenol is probably combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise the phenol from water. [Beilstein 13 IV 896.]

Properties of 2-Amino-4-nitrophenol

Melting point: 140-143 °C (lit.)
Boiling point: 322.46°C (rough estimate)
Density  1.3617 (estimate)
vapor pressure  0.005Pa at 25℃
refractive index  1.6890 (rough estimate)
Flash point: 100 °C
storage temp.  Refrigerator, Under Inert Atmosphere
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 6.82±0.22(Predicted)
color  Dark Yellow to Brown
Water Solubility  slightly soluble
BRN  776533
CAS DataBase Reference 99-57-0(CAS DataBase Reference)
IARC 3 (Vol. 57) 1993
EPA Substance Registry System 2-Amino-4-nitrophenol (99-57-0)

Safety information for 2-Amino-4-nitrophenol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Amino-4-nitrophenol

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