2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE
- CAS NO.：139047-55-5
- Empirical Formula: C21H23N5O
- Molecular Weight: 361.44
- MDL number: MFCD00673885
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
![2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE Structural](https://img.chemicalbook.in/StructureFile/ChemBookStructure3/GIF/CB8409227.gif)
What is 2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE?
The Uses of 2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE
2-PMDQ is an analog of Ketanserin with beneficial hemodynamic effects in portal hypertensive rats. Anti-hypertensive effects.
What are the applications of Application
2-PMDQ is a potent and selective antagonist of the α1-AR adrenoceptor
Definition
ChEBI: 2-[(4-phenyl-1-piperazinyl)methyl]-3,6-dihydro-2H-imidazo[1,2-c]quinazolin-5-one is a member of piperazines.
Biological Activity
Very potent ligand for α 1 sites (K i for displacement of prazosin = 0.2 nM). Also binds to 5-HT 1A sites (K i = 50 nM).
Properties of 2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble to 10 mM in DMSO and in ethanol |
| form | Powder |
| pka | 13.74±0.40(Predicted) |
Safety information for 2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE
Computed Descriptors for 2-[(4-PHENYLPIPERAZIN-1-YL)METHYL]-2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLIN-5(6H)-ONE
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