2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

CAS NO.：36341-25-0
Empirical Formula: C14H11NO2S
Molecular Weight: 257.31
MDL number: MFCD00030231
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE?

Biological Activity

YL-109 is a novel antitumor agent that inhibits the growth and invasion of breast cancer cells in vitro and in vivo.

in vitro

YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells.

Cell Proliferation Assay

< td class="col2"> MCF-7 and MDA-MB-231 cells

Cell Line:
Concentration:	0.001, 0.01, 0.1, 1, 10 μM
Incubation Time:	96 hours
Result:	Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC ₅₀ =85.8 nM and 4.02 μM, respectively).

in vivo

YL-109 (15 mg/kg; sc for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo.

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Animal Model:	BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells
Dosage:	15 mg/kg
Administration: < /td>	Sc every 2 days for 63 days
Result:	Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells.

Properties of 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

storage temp.	2-8°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml; Ethanol: 1 mg/ml
form	A crystalline solid
color	Light yellow to yellow

Safety information for 2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.