2-(4-Fluorophenyl)-thiophene

CAS NO.：58861-48-6
Empirical Formula: C10H7FS
Molecular Weight: 178.23
MDL number: MFCD06802535
EINECS: 611-756-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-28 15:15:04

What is 2-(4-Fluorophenyl)-thiophene?

Chemical properties

white solid

The Uses of 2-(4-Fluorophenyl)-thiophene

2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.

Synthesis

4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene.

Properties of 2-(4-Fluorophenyl)-thiophene

Melting point:	51.0 to 55.0 °C
Boiling point:	252.3±15.0 °C(Predicted)
Density	1.200±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	soluble in Methanol
form	powder to crystal
color	Light orange to Yellow to Green
InChI	InChI=1S/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H
CAS DataBase Reference	58861-48-6

Safety information for 2-(4-Fluorophenyl)-thiophene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.