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HomeProduct name list2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione

2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione

Synonym(s):1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline;2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione;2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1, ML-SA1;Mucolipin Synthetic Agonist 1;TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem

2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Structural

What is 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione?

Description

ML-SA1 (332382-54-4) is a?TRPML 1,2 and 3 channel activator.1?Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2?ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2?(1 μM).2?Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+?release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3?Reduces intralysosomal Ca2+?level rescuing abnormal lysosomal storage in FIG4-deficient cells.4

The Uses of 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione

ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.

Biochem/physiol Actions

ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca2+]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A.

storage

Store at +4°C

References

1) Grimm?et al. (2010),?Small molecule activators of TRPML3; Mol. Chem. Biol.,?17?135 2) Shen?et al. (2012),?Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release; Nature Commun.,?3?731 3) Weiss?et al. (2012),?Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases; Commun. Integer. Biol.,?5?111 4) Zou?et al. (2015),?Reactivation of lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells;J. Neurosci., 35?6801

Properties of 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione

Boiling point: 546.7±43.0 °C(Predicted)
Density  1.226±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: soluble5mg/mL, clear (warmed)
form  powder
pka 1.16±0.60(Predicted)
color  white to beige
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety information for 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Environment
GHS09
GHS Hazard Statements H301:Acute toxicity,oral
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P273:Avoid release to the environment.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P501:Dispose of contents/container to..…

Computed Descriptors for 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione

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