2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
- CAS NO.:35604-67-2
- Empirical Formula: C13H20ClNO3
- Molecular Weight: 273.7558
- MDL number: MFCD00661100
- EINECS: 252-638-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-08 16:27:35
What is 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride?
Chemical properties
Off-White Solid
Originator
Vivalan,I.C.I. ,UK,1974
The Uses of 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
Antidepressant.
The Uses of 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
Rac Viloxazine Hydrochloride is research useful chemical used as an antidepressant.
Manufacturing Process
2-Ethoxyphenol is first reacted with epichlorohydrin to give 1,2-epoxy-3-(o-
ethoxyphenoxy)-propane.
A mixture of crude (83%) 1,2-epoxy-3-(o-ethoxyphenoxy)propane (19.4
grams), 70.5 grams 2-aminoethyl hydrogen sulfate, 40.0 grams sodium
hydroxide, 400 ml ethanol and 200 ml water is stirred at 60°C for 18 hours
and is then evaporated to dryness. The residue is dissolved in 200 ml water
and the mixture is extracted three times with 150 ml of diethyl ether each
time. The combined extracts are dried over magnesium sulfate and
evaporated to dryness, The crude product (21.5 grams) is dissolved in
isopropanol (20 ml), 10.5 ml concentrated aqueous hydrochloric acid and 75
ml ethyl acetate are added and the mixture is cooled. The mixture is filtered
and there is thus obtained as solid product 2-(o-ethoxyphenoxymethyl)
morpholine hydrochloride, MP 179° to 182°C (8.6 grams; 38% yield based on
total epoxide used), according to US Patent 3,712,890.
Therapeutic Function
Psychotropic
Properties of 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
Melting point: | 178-180°C |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
color | White to Off-White |
Safety information for 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
Abamectin manufacturer
Maithri Drugs Pvt Ltd
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