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HomeProduct name list2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

  • CAS NO.:35604-67-2
  • Empirical Formula: C13H20ClNO3
  • Molecular Weight: 273.7558
  • MDL number: MFCD00661100
  • EINECS: 252-638-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-08 16:27:35
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Structural

What is 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride?

Chemical properties

Off-White Solid

Originator

Vivalan,I.C.I. ,UK,1974

The Uses of 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

Antidepressant.

The Uses of 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

Rac Viloxazine Hydrochloride is research useful chemical used as an antidepressant.

Manufacturing Process

2-Ethoxyphenol is first reacted with epichlorohydrin to give 1,2-epoxy-3-(o- ethoxyphenoxy)-propane.
A mixture of crude (83%) 1,2-epoxy-3-(o-ethoxyphenoxy)propane (19.4 grams), 70.5 grams 2-aminoethyl hydrogen sulfate, 40.0 grams sodium hydroxide, 400 ml ethanol and 200 ml water is stirred at 60°C for 18 hours and is then evaporated to dryness. The residue is dissolved in 200 ml water and the mixture is extracted three times with 150 ml of diethyl ether each time. The combined extracts are dried over magnesium sulfate and evaporated to dryness, The crude product (21.5 grams) is dissolved in isopropanol (20 ml), 10.5 ml concentrated aqueous hydrochloric acid and 75 ml ethyl acetate are added and the mixture is cooled. The mixture is filtered and there is thus obtained as solid product 2-(o-ethoxyphenoxymethyl) morpholine hydrochloride, MP 179° to 182°C (8.6 grams; 38% yield based on total epoxide used), according to US Patent 3,712,890.

Therapeutic Function

Psychotropic

Properties of 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

Melting point: 178-180°C
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
color  White to Off-White

Safety information for 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P330:Rinse mouth.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride

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