Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate
- CAS NO.:136285-65-9
- Empirical Formula: C14H18N2O6
- Molecular Weight: 310.3
- MDL number: MFCD09833364
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-09 13:11:54
What is Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate?
Acquired resistance
A mixture of ethyl 2-carboxy-3-nitrobenzoate(23.9 g) and thionyl chloride (12 ml) in benzene (150 ml) was heated under reflux for 3 hours. The reaction mixture was concentrated to dryness. The resultant acid chloride (26 g, quantitative) was dissolved in methylene chloride (20 ml). The solution was added dropwise to a mixture of sodium azide (9.75 g) in dimethylformamide(DMF) (20 ml) while stirring vigorously. The reaction mixture was poured into ether-hexane (3:1, 200 ml) and water (250 ml) to separate into two layers. The organic layer was washed with water and then dried, followed by evaporation of the solvent. The residue was dissolved in t-butanol (200 ml), and the solution was heated gradually with stirring, followed by heating under reflux for 2 hours. The reaction mixture was concentrated in vacuo to give an oily product Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate (30 g).
Properties of Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate
Boiling point: | 390.8±32.0 °C(Predicted) |
Density | 1.268 |
storage temp. | Sealed in dry,Room Temperature |
pka | 12.00±0.70(Predicted) |
Safety information for Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate
Computed Descriptors for Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate
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(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION XANTHAN GUM Racecadotril SODIUM VALPROATE Diclofenac Sodium Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN Folic Acid Impurity G Dabigatran Acyl-O2-D-Glucuronide Trifluoroacetic Acid Salt Glycopyrronium Bromide EP Impurity I Eltrombopag N-Oxide Impurity Di-Nitroso Acyclovir Impurity K DLRD N-OxideRelated products of tetrahydrofuran
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