(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
- CAS NO.:365997-33-7
- Empirical Formula: C14H25NO5
- Molecular Weight: 287.35
- MDL number: MFCD23106245
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-29 08:58:18
What is (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester?
The Uses of (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
Ethyl (1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate, is a building block used in various chemicla synthesis. It can be used for the preparation of six stereoisomers of diaminocyclohexane carboxamide as key intermediates for synthesis of factor Xa inhibitors.
Preparation
Under 45°C, aqueous ammonia(175 mL) was added to the (1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylate ethyl (17g, 0.1mmol). After TLC confirmed that the reaction was completed, the reaction liquid was vacuum concentrated. Then 175 mL ethanol was added to the reaction. At room temperature, di-tert-butyl dicarbonate (44.0g, 201mmol) dissolved in ethanol would be added to the above mixture. After reaction for 1h, the solid was concentrated in vacuo, and water (300 mL) was added to the mixture.The water layer was extracted with ethanol (300 mL) twice. The organic phase was collected and dried with anhydrous sodium sulfate. After vacuum concentration, the residue was purified by column chromatography on silica gel to obtain (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester.
Properties of (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
Melting point: | 93-95°C |
Boiling point: | 406.6±45.0 °C(Predicted) |
Density | 1.12±0.1 g/cm3(Predicted) |
storage temp. | Refrigerator |
solubility | Chloroform (Sparingly), DMSO (Slightly), Ethyl Acetate (Slightly) |
form | Solid |
pka | 11.73±0.60(Predicted) |
color | White to Off-White |
Safety information for (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
Computed Descriptors for (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
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ExSyn Corp
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