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HomeProduct name list(1R,2S,3S)-Aprepitant

(1R,2S,3S)-Aprepitant

  • CAS NO.:172822-28-5
  • Empirical Formula: C23H21F7N4O3
  • Molecular Weight: 534.43
  • Update Date: 2024-06-11 18:14:38
(1R,2S,3S)-Aprepitant Structural

What is (1R,2S,3S)-Aprepitant?

The Uses of (1R,2S,3S)-Aprepitant

(2S,3S,1’R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. (2S,3S,1’R)-Aprepitant is also a useful synthetic intermediate in the synthesis of morpholine tachykinin receptor antagonist prodrugs.

Properties of (1R,2S,3S)-Aprepitant

Density  1.51±0.1 g/cm3(Predicted)
pka 8.06±0.20(Predicted)

Safety information for (1R,2S,3S)-Aprepitant

Computed Descriptors for (1R,2S,3S)-Aprepitant

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