(1R,2S,3R)-Aprepitant
- CAS NO.:1185502-97-9
- Empirical Formula: C23H21F7N4O3
- Molecular Weight: 534.43
- MDL number: MFCD24386574
- Update Date: 2024-06-11 18:14:38
What is (1R,2S,3R)-Aprepitant?
The Uses of (1R,2S,3R)-Aprepitant
(2S,3R,1’R)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
Definition
ChEBI: 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-1,2,4-triazol-3-one is a member of morpholines.
Properties of (1R,2S,3R)-Aprepitant
Density | 1.51±0.1 g/cm3(Predicted) |
pka | 8.06±0.20(Predicted) |
Safety information for (1R,2S,3R)-Aprepitant
Computed Descriptors for (1R,2S,3R)-Aprepitant
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
Aprepitant Impurity 19
Benzyl dihydrogen phosphate
(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
Aprepitant
Fosaprepitant dimeglumine
5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one
Aprepitant
Aprepitant
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