Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list1H-1-Ethyl Candesartan Cilexetil

1H-1-Ethyl Candesartan Cilexetil

1H-1-Ethyl Candesartan Cilexetil Structural

What is 1H-1-Ethyl Candesartan Cilexetil?

Chemical properties

White Solid

The Uses of 1H-1-Ethyl Candesartan Cilexetil

Candesartan Cilexetil Impurity E (PHARMEUROPA).

What are the applications of Application

1H-1-Ethyl Candesartan Cilexetil is a Candesartan Cilexetil impurity

Biological Activity

1h-1-ethyl candesartan cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin ii type 1 receptor (at1) antagonist.angiotensin ii is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including at1[1]. at1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. furthermore, at1 mediates the classical biological actions of angiotensin ii. also, at1 has seven helical transmembrane domains, which is the characteristic of the superfamily of g-protein-coupled receptors. carboxyl-terminal region structure of at1 plays important roles in receptor internalization, desensitization and phosphorylation [2].

References

[1]. otsuka, m. reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin ii type 1 receptor antagonist. thorax. 2004; 59(1): 31-38.
[2]. guo, d., sun, y., hamet, p., & inagami, t. the angiotensin ii type 1 receptor and receptor-associated proteins. cell research. 2001; 11(3): 165-180.

Properties of 1H-1-Ethyl Candesartan Cilexetil

Melting point: 90-93°C
Boiling point: 842.0±75.0 °C(Predicted)
Density  1.32
storage temp.  Refrigerator
solubility  ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide
form  crystalline solid
pka 3.95±0.10(Predicted)

Safety information for 1H-1-Ethyl Candesartan Cilexetil

Computed Descriptors for 1H-1-Ethyl Candesartan Cilexetil

Related products of tetrahydrofuran

You may like

  • Candesartan Cilexetil Impurity-E 98%
    Candesartan Cilexetil Impurity-E 98%
    914613-35-7
    View Details
  • Candesartan Cilexetil Impurity E CAS 914613-35-7
    Candesartan Cilexetil Impurity E CAS 914613-35-7
    914613-35-7
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • 1784294-80-9 98%
    1784294-80-9 98%
    1784294-80-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.