1H-1-Ethyl Candesartan Cilexetil
- CAS NO.:914613-35-7
- Empirical Formula: C35H38N6O6
- Molecular Weight: 638.71282
- MDL number: MFCD18382323
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 18:15:48
What is 1H-1-Ethyl Candesartan Cilexetil?
Chemical properties
White Solid
The Uses of 1H-1-Ethyl Candesartan Cilexetil
Candesartan Cilexetil Impurity E (PHARMEUROPA).
What are the applications of Application
1H-1-Ethyl Candesartan Cilexetil is a Candesartan Cilexetil impurity
Biological Activity
1h-1-ethyl candesartan cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin ii type 1 receptor (at1) antagonist.angiotensin ii is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including at1[1]. at1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. furthermore, at1 mediates the classical biological actions of angiotensin ii. also, at1 has seven helical transmembrane domains, which is the characteristic of the superfamily of g-protein-coupled receptors. carboxyl-terminal region structure of at1 plays important roles in receptor internalization, desensitization and phosphorylation [2].
References
[1]. otsuka, m. reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin ii type 1 receptor antagonist. thorax. 2004; 59(1): 31-38.
[2]. guo, d., sun, y., hamet, p., & inagami, t. the angiotensin ii type 1 receptor and receptor-associated proteins. cell research. 2001; 11(3): 165-180.
Properties of 1H-1-Ethyl Candesartan Cilexetil
Melting point: | 90-93°C |
Boiling point: | 842.0±75.0 °C(Predicted) |
Density | 1.32 |
storage temp. | Refrigerator |
solubility | ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide |
form | crystalline solid |
pka | 3.95±0.10(Predicted) |
Safety information for 1H-1-Ethyl Candesartan Cilexetil
Computed Descriptors for 1H-1-Ethyl Candesartan Cilexetil
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