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HomeProduct name list17ALPHA-HYDROXYPREGNENOLONE

17ALPHA-HYDROXYPREGNENOLONE

Synonym(s):3β,17α-Dihydroxy-5-pregnen-20-one;5-Pregnene-3β,17α-diol-20-one

  • CAS NO.:387-79-1
  • Empirical Formula: C21H32O3
  • Molecular Weight: 332.48
  • MDL number: MFCD00021129
  • EINECS: 206-862-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-01 15:07:50
17ALPHA-HYDROXYPREGNENOLONE Structural

What is 17ALPHA-HYDROXYPREGNENOLONE?

Description

17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.

The Uses of 17ALPHA-HYDROXYPREGNENOLONE

17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.

What are the applications of Application

17α-Hydroxypregnenolone is a C21 steroid and prohormone in the formation of DHEA

General Description

17α-hydroxypregnenolone is a derived from pregnenolone.

Biochem/physiol Actions

17α-hydroxypregnenolone acts as a precursor for cortisol and sex steroids.

Properties of 17ALPHA-HYDROXYPREGNENOLONE

Melting point: 273℃
Flash point: 9℃
storage temp.  -20°C
solubility  Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated)
form  Solid
Boiling point: 478.4±45.0 °C(Predicted)
Density  1.15±0.1 g/cm3(Predicted)
pka 13.02±0.70(Predicted)
color  White to Off-White
CAS DataBase Reference 387-79-1(CAS DataBase Reference)

Safety information for 17ALPHA-HYDROXYPREGNENOLONE

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P311:Call a POISON CENTER or doctor/physician.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for 17ALPHA-HYDROXYPREGNENOLONE

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