17ALPHA-HYDROXYPREGNENOLONE
Synonym(s):3β,17α-Dihydroxy-5-pregnen-20-one;5-Pregnene-3β,17α-diol-20-one
- CAS NO.：387-79-1
- Empirical Formula: C21H32O3
- Molecular Weight: 332.48
- MDL number: MFCD00021129
- EINECS: 206-862-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is 17ALPHA-HYDROXYPREGNENOLONE?
Description
17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.
The Uses of 17ALPHA-HYDROXYPREGNENOLONE
17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.
What are the applications of Application
17α-Hydroxypregnenolone is a C21 steroid and prohormone in the formation of DHEA
General Description
17α-hydroxypregnenolone is a derived from pregnenolone.
Biochem/physiol Actions
17α-hydroxypregnenolone acts as a precursor for cortisol and sex steroids.
Properties of 17ALPHA-HYDROXYPREGNENOLONE
| Melting point: | 273℃ |
| Flash point: | 9℃ |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated) |
| form | Solid |
| Boiling point: | 478.4±45.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| pka | 13.02±0.70(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 387-79-1(CAS DataBase Reference) |
Safety information for 17ALPHA-HYDROXYPREGNENOLONE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 17ALPHA-HYDROXYPREGNENOLONE
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