1,4-PHENYLENE DIISOTHIOCYANATE
Synonym(s):1,4-Diisothiocyanatobenzene;Bitoscanate;PDITC
- CAS NO.:4044-65-9
- Empirical Formula: C8H4N2S2
- Molecular Weight: 192.26
- MDL number: MFCD00004811
- EINECS: 223-741-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is 1,4-PHENYLENE DIISOTHIOCYANATE?
Description
Bitoscanate is a colorless to beige, odorless,crystalline compound. Molecular weight=192.3; Freezing/Melting point=132℃. Hazard Identification (based onNFPA-704 M Rating System): Health 2, Flammability 1,Reactivity 0.
Chemical properties
off-white to yellow to beige-grey crystalline
Chemical properties
Those engaged in the manufacture, formulation and application of this anthelmintic compound. Incompatibilities: In general, keep away from strong oxidizers, moisture, strong acids, strong bases. This is a thiocyanate compound. Violent reactions may occur upon contact with chlorates (potassium chlorate, sodium chlorate), nitrates, nitric acid; organic peroxides.
The Uses of 1,4-PHENYLENE DIISOTHIOCYANATE
Reagent for solid-phase sequencing.
The Uses of 1,4-PHENYLENE DIISOTHIOCYANATE
anthelmintic
The Uses of 1,4-PHENYLENE DIISOTHIOCYANATE
It is used in the treatment of?hookworms.
Definition
ChEBI: Bitoscanate is a member of benzenes.
General Description
Odorless colorless crystals. Melting point 132°C.
Reactivity Profile
1,4-PHENYLENE DIISOTHIOCYANATE reacts readily with amines [Noller]. These reactions may generate significant amounts of heat . Emits very toxic fumes of nitrogen oxides and sulfur oxides when heated to decomposition [EPA, 1998].
Health Hazard
1,4-PHENYLENE DIISOTHIOCYANATE is highly toxic if ingested. It is a central nervous system and gastrointestinal toxin in humans.
Fire Hazard
When heated to decomposition, 1,4-PHENYLENE DIISOTHIOCYANATE emits very toxic fumes of nitrogen oxides and sulfur oxides.
Safety Profile
Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: hallucinations, nausea. When heated to decomposition it emits very toxic fumes of NOx,CN,and SOx.See also THIOCYANATES
Potential Exposure
Those engaged in the manufacture, formulation and application of this anthelmintic compound. Incompatibilities: In general, keep away from strong oxidizers, moisture, strong acids, strong bases. This is a thiocyanate compound. Violent reactions may occur upon contact with chlorates (potassium chlorate, sodium chlorate), nitrates, nitric acid; organic peroxides.
First aid
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contactsthe skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove fromexposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing hasstopped and CPR if heart action has stopped. Transferpromptly to a medical facility. When this chemical hasbeen swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. For cyanide poisoning, use amylnitrate capsules if symptoms develop. All area employeesshould be trained regularly in emergency measures for cyanide poisoning and in CPR. A cyanide antidote kit shouldbe kept in the immediate work area and must be rapidlyavailable. Kit ingredients should be replaced every 1 2years to ensure freshness. Persons trained in the use of thiskit, oxygen use, and CPR must be quickly available.
storage
Color Code—Green: General storage may be used.Store in tightly closed containers in a cool, well-ventilatedarea. Store under inert gas; moisture sensitive.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required.
Purification Methods
Purify bitoscanate by recrystallisation from AcOH, pet ether (b 40-60o), Me2CO or aqueous Me2CO. [van der Kerk et al. Recl Trav Chim Pays-Bas 74 1262 1955, Leiber & Slutkin J Org Chem 27 2214 1962, Beilstein 13 IV 174.]
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Properties of 1,4-PHENYLENE DIISOTHIOCYANATE
Melting point: | 129-131 °C (lit.) |
Boiling point: | 339.4±25.0 °C(Predicted) |
Density | 1.3675 (rough estimate) |
refractive index | 1.6000 (estimate) |
storage temp. | −20°C |
solubility | chloroform: clear |
form | powder |
color | white |
Water Solubility | Hydrolyzes in water. |
Sensitive | Moisture Sensitive |
Merck | 14,1308 |
BRN | 2414340 |
CAS DataBase Reference | 4044-65-9(CAS DataBase Reference) |
EPA Substance Registry System | Bitoscanate (4044-65-9) |
Safety information for 1,4-PHENYLENE DIISOTHIOCYANATE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,4-PHENYLENE DIISOTHIOCYANATE
InChIKey | OMWQUXGVXQELIX-UHFFFAOYSA-N |
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