1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE
Synonym(s):2-Hydroxymethyl-3,4-pyrrolidinediol hydrochloride
- CAS NO.：100991-92-2
- Empirical Formula: C5H12ClNO3
- Molecular Weight: 169.61
- MDL number: MFCD03427380
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:12
What is 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE?
Description
1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC50 = 1.0 μM) and in homogenates of cerebral cortex and cerebellum (IC50s = 463 and 383 nM, respectively). DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models.
The Uses of 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride has been used as an α-glucosidase (GAA) inhibitor.
What are the applications of Application
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride is a glycogen phosphorylase inhibitor
General Description
1,4-Dideoxy-1,4-imino-D-arabinitol is a naturally occurring pyrrolidine alkaloid. It is found in Arachniodes standishii and Angylocalyx boutiqueanus.
Biochem/physiol Actions
Inhibitor of glycogen phosphorylase and α-glucosidases.
Properties of 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE
| Melting point: | 110-112 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1)) |
| storage temp. | 2-8°C |
| solubility | DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml |
| form | A crystalline solid |
Safety information for 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE
Computed Descriptors for 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE
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