14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
Synonym(s):ent-(3β,11E)-3,19-Dihydroxy-8(17),11,13-labdatrien-16,15-olide;3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 2(5H)-furanone
- CAS NO.：42895-58-9
- Empirical Formula: C20H28O4
- Molecular Weight: 332.43
- MDL number: MFCD07778081
- EINECS: 226-852-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE?
Description
14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 μg/ml) that can occur with andrographolide 6.5 μg/ml.
The Uses of 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
14-Deoxy-11,12-didehydroandrographolide is the derivative of Andrographolide(A637475) is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.
Definition
ChEBI: 14-Deoxy-11,12-didehydroandrographolide is a diterpene lactone. It has a role as a metabolite.
Properties of 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
| Melting point: | 204-205℃ |
| Boiling point: | 519.6±50.0 °C(Predicted) |
| Density | 1.17 |
| storage temp. | Store at -20°C |
| solubility | DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml |
| pka | 14.80±0.70(Predicted) |
| form | neat |
| form | Solid |
| color | White to off-white |
Safety information for 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
Computed Descriptors for 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
New Products
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