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HomeProduct name list14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

Synonym(s):ent-(3β,11E)-3,19-Dihydroxy-8(17),11,13-labdatrien-16,15-olide;3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]- 2(5H)-furanone

  • CAS NO.:42895-58-9
  • Empirical Formula: C20H28O4
  • Molecular Weight: 332.43
  • MDL number: MFCD07778081
  • EINECS: 226-852-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 13:32:20
14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE Structural

What is 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE?

Description

14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide that can be isolated from A. paniculata. It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 μg/ml) that can occur with andrographolide 6.5 μg/ml.

The Uses of 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

14-Deoxy-11,12-didehydroandrographolide is the derivative of Andrographolide(A637475) is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.

Definition

ChEBI: 14-Deoxy-11,12-didehydroandrographolide is a diterpene lactone. It has a role as a metabolite.

Properties of 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

Melting point: 204-205℃
Boiling point: 519.6±50.0 °C(Predicted)
Density  1.17
storage temp.  Store at -20°C
solubility  DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml
pka 14.80±0.70(Predicted)
form  neat
form  Solid
color  White to off-white

Safety information for 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

Computed Descriptors for 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE

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