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HomeProduct name list1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

Synonym(s):TIPDSiCl2

  • CAS NO.:69304-37-6
  • Empirical Formula: C12H28Cl2OSi2
  • Molecular Weight: 315.43
  • MDL number: MFCD00009655
  • EINECS: 629-558-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-03-25 11:48:53
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane Structural

What is 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane?

Chemical properties

Colorless liquid

Physical properties

bp 70°C/0.5 mmHg; d 0.986 g cm?3.

The Uses of 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. Also used in the formation of ribavirin chemical delivery systems.

The Uses of 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane can be used as simultaneous protection of the 3'- and 5'-hydroxyl functions of furanose nucleosides;protecting group for carbohydrates;3,4 protecting group reagent for open-chain polyhydroxy compounds; preparation of cyclic bridged peptides.
The reagent design was based upon the fact that triisopropylsilyl chloride reacts 1000 times faster with primary alcohols than secondary alcohols. Thus in the case of 3',5'-dihydroxy nucleosides the reagent initially silylates at the 5'-position. This is then followed by intramolecular reaction with the secondary alcohol at the 3'-position to give the doubly protected derivative (eq 1).intramolecular reaction

The Uses of 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3'- and 5'-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.

Preparation

can be prepared starting from trichlorosilane by treatment with i-PrMgCl, H2O, and acetyl chloride. Alternatively, it can be prepared by the reaction of 1,1,3,3- tetraisopropyldisiloxane with CCl4 in the presence of catalytic PdCl2.This method is also suitable for its in situ preparation.

Properties of 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

Boiling point: 70 °C0.5 mm Hg(lit.)
Density  0.986 g/mL at 25 °C(lit.)
refractive index  n20/D 1.454(lit.)
Flash point: >230 °F
storage temp.  Inert atmosphere,2-8°C
solubility  Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.
form  Oil
Specific Gravity 0.986
color  Colourless
Sensitive  Moisture Sensitive
Hydrolytic Sensitivity 8: reacts rapidly with moisture, water, protic solvents
BRN  1934216
InChI InChI=1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3
CAS DataBase Reference 69304-37-6(CAS DataBase Reference)

Safety information for 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H290:Corrosive to Metals
H314:Skin corrosion/irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

Computed Descriptors for 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

InChIKey DDYAZDRFUVZBMM-UHFFFAOYSA-N
SMILES [Si](Cl)(C(C)C)(C(C)C)O[Si](Cl)(C(C)C)C(C)C

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