1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

Synonym(s):1,2,3,4,5,6-Hexabromocyclohexane;Benzene hexabromide;JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem;NSC 7908

CAS NO.：1837-91-8
Empirical Formula: C6H6Br6
Molecular Weight: 557.54
MDL number: MFCD00059127
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Structural

What is 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE?

The Uses of 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.

What are the applications of Application

1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation

Definition

ChEBI: 1,2,3,4,5,6-hexabromocyclohexane is a bromohydrocarbon that is cyclohexane in which the hydrogen at positions 1,2,3,4,5 and 6 have been replaced by bromo groups. It is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a bromohydrocarbon and a bromoalkane. It derives from a hydride of a cyclohexane.

Biological Activity

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M.

storage

Room temperature

Properties of 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

Melting point:	218.0 to 223.0 °C
storage temp.	Store at RT
solubility	DMSO: soluble2mg/mL (clear solution, warmed)
form	powder
color	white to beige
CAS DataBase Reference	1837-91-8(CAS DataBase Reference)
EPA Substance Registry System	Cyclohexane, 1,2,3,4,5,6-hexabromo- (1837-91-8)

Safety information for 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention.