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HomeProduct name list1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER

1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER

  • CAS NO.:635-03-0
  • Empirical Formula: C15H24O8
  • Molecular Weight: 332.35
  • MDL number: MFCD00027834
  • EINECS: 211-222-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 17:06:35
1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER Structural

What is 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER?

The Uses of 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER

1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

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Condensation of diethylfumarate and diethylmalonate to propane-1,1,2,3 tetracarboxylate. Catalyst specifications: Catalytic entity: Ph(CH2)-N+(PhmSO3-)3 · EtO- (1 milieq of EtO-), additive:: Sodium meta silicate 1 gm, Support: Charcoal 5 gm, Group IIA metal salt: Barium hydroxide, Method of preparation: Deposition precipitation. Procedure: in a 100-ml flask fitted with an efficient reflux condenser, magnetic stirrer bar and dropping funnel was charged 5 gm of catalyst. With stirring 1.6 g (0.001 mol) diethylmalonate and 25 ml dry ethanol was added. Reaction mixture was warmed and 1.4 gm (0.0081 mol) diethyl fumarate was added. Mixture was refluxed for 8 hours. Reaction mixture was cooled and suspension was centrifuged to recover catalyst. Analysis of reaction liquid indicated 90 % conversion for diethylmalonate. Product was distilled under vacuum 8 mm at 180-190°C to obtain propane-1,1,2,3 tetracarboxylate 85% yield. Catalyst was recovered and washed with ethanol, diethyl ether and dried under vacuum. Catalyst was recycled to obtain equivalent activity.

Properties of 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER

Boiling point: 389.48°C (rough estimate)
Density  1.1184
refractive index  1.4380-1.4420
pka 11.42±0.59(Predicted)
form  clear liquid
color  Colorless to Almost colorless

Safety information for 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER

Computed Descriptors for 1,1,2,3-PROPANETETRACARBOXYLIC ACID TETRAETHYL ESTER

InChIKey WGEVJRBJWMGTSI-UHFFFAOYSA-N

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