1,1,2-Trimethyl-1H-benz[e]indole

CAS NO.：41532-84-7
Empirical Formula: C15H15N
Molecular Weight: 209.29
MDL number: MFCD00082627
EINECS: 255-429-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-06 17:55:34

What is 1,1,2-Trimethyl-1H-benz[e]indole?

Chemical properties

yellow to brown crystalline powder

The Uses of 1,1,2-Trimethyl-1H-benz[e]indole

1,1,2-Trimethyl-1H-benzo[e]indole can be used as an indole pH fluorescent probe and can be used for intracellular pH detection and cell marking. It can also be used as a novel nanocarrier-based near-infrared optical probes for in-vivo tumor imaging.

Synthesis

Isopropyl methyl ketone (9.00 g, 0.1 mol) was added to a solution of 2-naphthylhydrazine hydrochloride (15.80 g, 0.1 mol) in glacial acetic acid (100 mL). The mixture was stirred for 0.5 h at 20 °C and refluxed for 6 h. Then, the reaction mixture was poured onto ice and neutralized with sodium carbonate, a precipitate formed was collected by filtration. The yield was 19.8 g (95%).
1,1,2-Trimethyl-1H-benz[e]indole

Properties of 1,1,2-Trimethyl-1H-benz[e]indole

Melting point:	111-117 °C
Boiling point:	338.66°C (rough estimate)
Density	0.7
refractive index	1.5720 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	insoluble (20°C)
form	Crystalline Powder
pka	5.77±0.40(Predicted)
color	Yellow to brown
Water Solubility	insoluble (20 ºC)
BRN	153709
InChI	InChI=1S/C15H15N/c1-10-15(2,3)14-12-7-5-4-6-11(12)8-9-13(14)16-10/h4-9H,1-3H3
CAS DataBase Reference	41532-84-7(CAS DataBase Reference)
EPA Substance Registry System	1H-Benz[e]indole, 1,1,2-trimethyl- (41532-84-7)

Safety information for 1,1,2-Trimethyl-1H-benz[e]indole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.