1,1,1-Trifluoroacetone
- CAS NO.：421-50-1
- Empirical Formula: C3H3F3O
- Molecular Weight: 112.05
- MDL number: MFCD00000423
- EINECS: 207-005-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 1,1,1-Trifluoroacetone?
Chemical properties
1,1,1-Trifluoroacetone is CLEAR COLOURLESS LIQUID
The Uses of 1,1,1-Trifluoroacetone
1,1,1-Trifluoroacetone is used as intermediate of bioactive substance and antihypertensive drug, and as effective synthetic building block and trifluoromethyl reaction reagent.
The Uses of 1,1,1-Trifluoroacetone
1,1,1-Trifluoroacetone is a general chemical reagent used in the synthesis of glucokinase-glucokinase regulatory protein) GK-GKRP disruptors which may act as potential targets for type II diabetics. Reactant for enantioselective cycloadditions.
The Uses of 1,1,1-Trifluoroacetone
Used in a synthesis of 2-trifluoromethyl-7-azaindoles starting with 2,6-dihalopyridines. The derived chiral imine was used to prepare enantiopure α-trifluoromethyl alanines and diamines via a Strecker reaction followed by either nitrile hydrolysis or reduction.
Properties of 1,1,1-Trifluoroacetone
| Melting point: | -78 °C |
| Boiling point: | 22 °C(lit.) |
| Density | 1.252 g/mL at 25 °C(lit.) |
| vapor pressure | 13.62 psi ( 20 °C) |
| refractive index | n |
| Flash point: | −23 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Methanol |
| form | Liquid |
| color | Clear colorless |
| Water Solubility | Miscible |
| Sensitive | Lachrymatory |
| BRN | 1748614 |
| Stability: | Volatile |
| CAS DataBase Reference | 421-50-1(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Propanone, 1,1,1-trifluoro-(421-50-1) |
| EPA Substance Registry System | 2-Propanone, 1,1,1-trifluoro- (421-50-1) |
Safety information for 1,1,1-Trifluoroacetone
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H224:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for 1,1,1-Trifluoroacetone
| InChIKey | FHUDAMLDXFJHJE-UHFFFAOYSA-N |
Abamectin manufacturer
VGS SYNTHESIS PRIVATE LIMITED
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product: 421-50-1 1,1,1-trifluoro-2-propanone 98%
SRF Limited
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Phone:+91-9650533660
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product: 1,1,1-Trifluoro-2-propanone 98%
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