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HomeProduct name list1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid

1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid

  • CAS NO.:64096-87-3
  • Empirical Formula: C6H10O4S
  • Molecular Weight: 178.21
  • MDL number: MFCD03102802
  • EINECS: 815-471-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-08 14:34:03
1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid Structural

What is 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid?

Synthesis

3,3-Dimethyl- 2, 4-dioxa-9-thiaspiro[5.5]undecane-1,5-dione-9, 9-dioxide 1 (20.0 g, 76.3 mmol) and then 6 N hydrochloric acid (60 mL) and Antifoam 204 (200 mg, 1 wt % relative to 1) were charged to a 250-mL, three-neck round-bottom flask, equipped with a mechanical stirrer and a thermocouple. The reaction was then heated to reflux, and the distillate was collected until the internal temperature reached 100 eC; after that, the reaction was allowed to reflux for an additional 8 hours or until LC/MS showed a complete conversion of 1 to 2. The reaction was then cooled to room temperature and held for ~12 h when the product crystallized from the solution. The slurry was cooled to 0 °C for 1 h and then filtered. The cake was dried in a vacuum oven at 60 eC, with nitrogen bleed, overnight to give the product as a white, crystalline solid 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid (8.84 g, 49.6 mmol, 65% yield.
1,1-Dioxo-hexahydro-1l6-thiopyran-4-carboxylic acid

Properties of 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid

Melting point: 195-196℃ (acetone ligroine )
Boiling point: 456.6±38.0 °C(Predicted)
Density  1.422±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
pka 4.05±0.20(Predicted)
color  White to off-white

Safety information for 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid

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