1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid
- CAS NO.:64096-87-3
- Empirical Formula: C6H10O4S
- Molecular Weight: 178.21
- MDL number: MFCD03102802
- EINECS: 815-471-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-08 14:34:03
What is 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid?
Synthesis
3,3-Dimethyl- 2, 4-dioxa-9-thiaspiro[5.5]undecane-1,5-dione-9, 9-dioxide 1 (20.0 g, 76.3 mmol) and then 6 N hydrochloric acid (60 mL) and Antifoam 204 (200 mg, 1 wt % relative to 1) were charged to a 250-mL, three-neck round-bottom flask, equipped with a mechanical stirrer and a thermocouple. The reaction was then heated to reflux, and the distillate was collected until the internal temperature reached 100 eC; after that, the reaction was allowed to reflux for an additional 8 hours or until LC/MS showed a complete conversion of 1 to 2. The reaction was then cooled to room temperature and held for ~12 h when the product crystallized from the solution. The slurry was cooled to 0 °C for 1 h and then filtered. The cake was dried in a vacuum oven at 60 eC, with nitrogen bleed, overnight to give the product as a white, crystalline solid 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid (8.84 g, 49.6 mmol, 65% yield.
Properties of 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid
Melting point: | 195-196℃ (acetone ligroine ) |
Boiling point: | 456.6±38.0 °C(Predicted) |
Density | 1.422±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
pka | 4.05±0.20(Predicted) |
color | White to off-white |
Safety information for 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,1-Dioxo-tetrahydrothiopyran-4-carboxylic acid
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