1,1-Dichloro-2,2,2-trifluoroethane
Synonym(s):2,2-Dichloro-1,1,1-trifluoroethane solution
- CAS NO.:306-83-2
- Empirical Formula: C2HCl2F3
- Molecular Weight: 152.93
- MDL number: MFCD00042132
- EINECS: 206-190-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 1,1-Dichloro-2,2,2-trifluoroethane?
Chemical properties
1,1-Dichloro-2,2,2-trifluoroethane has a light ethereal odor with poor warning properties.
The Uses of 1,1-Dichloro-2,2,2-trifluoroethane
HCFC 123 is an interim replacement for the CFCs and is scheduled for a production phase-out during the 2020s. Its main application is as a substitute for CFC 11 in centrifugal chillers used for air conditioning of large buildings. It is also used in smaller air-conditioning units, and may have applications in foam blowing, and firefighting and as a chemical intermediate.
General Description
Colorless nonflammable gas. Nearly odorless.
Reactivity Profile
1,1-Dichloro-2,2,2-trifluoroethane is chemically inert in many situations, but can react violently with strong reducing agents such as the very active metals and the active metals. They suffer oxidation with strong oxidizing agents and under extremes of temperature.
Health Hazard
HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) has evidenced significant human liver toxicity. A group of 17 workers suffered liver damage in a 1997 outbreak. They were involved in containerizing this liquid. HCFC-123 is chemically similar to halothane and has the same toxic metabolite. HCFC- 123 exposure also was implicated as the cause of liver disease in nine industrial workers who had repeated exposure because of a leaking airconditioning system in 1996; the refrigerant also contained HCFC-124. HCFC-124 and HCFC-125 are also structurally similar to halothane.
Flammability and Explosibility
Non flammable
Safety Profile
Suspected carcinogen. Moderately toxic by inhalation. When heated to decomposition it emits very toxic fumes of Fand Cl-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and FLUORIDES.
Carcinogenicity
An inhalation toxicity/oncogenicity study was conducted with groups of 80 male and 80 female rats. This study was described earlier in this section. In addition to the effects on serum chemistry parameters and the retina, increases in benign tumors of the pancreas, testes, and liver were reported. As noted above, the survival in the HCFC 123–exposed animals was better than in the airexposed controls. These tumors tended to appear near the end of the study and generally were not considered to be the cause of death.
Properties of 1,1-Dichloro-2,2,2-trifluoroethane
Melting point: | -107°C |
Boiling point: | 27.6°C |
Density | 1,475 g/cm3 |
vapor pressure | 93.456kPa at 25.62℃ |
refractive index | 1.3290 |
Flash point: | 9℃ |
storage temp. | 2-8°C |
form | A liquid |
Water Solubility | 2.1g/L at 25℃ |
CAS DataBase Reference | 306-83-2(CAS DataBase Reference) |
NIST Chemistry Reference | Ethane, 2,2-dichloro-1,1,1-trifluoro-(306-83-2) |
EPA Substance Registry System | HCFC-123 (306-83-2) |
Safety information for 1,1-Dichloro-2,2,2-trifluoroethane
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure H420:Hazardous to the ozone layer |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 1,1-Dichloro-2,2,2-trifluoroethane
New Products
2,2-diethoxyethanethioamide Tubulysin D (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin E Tubulysin C Tubulysin H Potassium HMDS (1.0 M in THF) Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-Aminocyclobutanone hydrochloride 1-(1,1-Difluoroethyl)-2-fluorobenzene 4-(Benzyloxy)-3-bromophenylacetic Acid Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate CYCLOBUTYLAMINE HYDROCHLORIDE (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH Fuel shell Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateRelated products of tetrahydrofuran
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