1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol
- CAS NO.：101597-25-5
- Empirical Formula: C17H16O3
- Molecular Weight: 268.31
- MDL number: MFCD00420323
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:35
What is 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol?
The Uses of 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol
1,1-bis(4-Methoxyphenyl)-2-propyn-1-ol (cas# 101597-25-5) is used in the synthetic preparation of photochromic pyranobenzopyran derivatives.
Preparation
The preparation of 1,1-bis(4-methoxyphenyl)-2-propyn-1-ol is as follows:18W % sodium acetylide in xylene/mineral oil 121.1mL (0.45mol, 1eq) was dissolved in anhydrous THF (1L) saturated with acetylene gas. After that 4,4-dimethoxybenzophenone 100g (0.41mol, 1eq) was put inside the reaction mixture under nitrogen and stirred for 24h at room temperature. The product was extracted by solvent extraction using ethyl acetate and water, organic layer was dried with MgSO4 and solid product on vacuum drier. After complete drying, the product again dissolve in ethyl acetate and poured into 1L hexane slowly under stirring which afford 8 as white color solid, yield (99g, 90%).
Properties of 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol
| Melting point: | 91.9-92.2℃ |
| Boiling point: | 412.0±45.0 °C(Predicted) |
| Density | 1.156 |
| storage temp. | 2-8°C |
| form | powder to crystal |
| pka | 11.72±0.29(Predicted) |
| color | White to Almost white |
Safety information for 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 4-Hydrazinobenzoic acid 3,4-Dibenzyloxybenzaldehyde 3-Nitrobenzaldehyde 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) 4-HYDROXY BENZYL ALCOHOL 3-NITRO-2-METHYL ANILINE (2-Hydroxyphenyl)acetonitrile 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride tert-butyl 4- (ureidomethyl)benzylcarbamate diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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