1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol

CAS NO.：101597-25-5
Empirical Formula: C17H16O3
Molecular Weight: 268.31
MDL number: MFCD00420323
EINECS: 1592732-453-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:35

What is 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol?

The Uses of 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol

1,1-bis(4-Methoxyphenyl)-2-propyn-1-ol (cas# 101597-25-5) is used in the synthetic preparation of photochromic pyranobenzopyran derivatives.

Preparation

The preparation of 1,1-bis(4-methoxyphenyl)-2-propyn-1-ol is as follows:18W % sodium acetylide in xylene/mineral oil 121.1mL (0.45mol, 1eq) was dissolved in anhydrous THF (1L) saturated with acetylene gas. After that 4,4-dimethoxybenzophenone 100g (0.41mol, 1eq) was put inside the reaction mixture under nitrogen and stirred for 24h at room temperature. The product was extracted by solvent extraction using ethyl acetate and water, organic layer was dried with MgSO4 and solid product on vacuum drier. After complete drying, the product again dissolve in ethyl acetate and poured into 1L hexane slowly under stirring which afford 8 as white color solid, yield (99g, 90%).

Properties of 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol

Melting point:	91.9-92.2℃
Boiling point:	412.0±45.0 °C(Predicted)
Density	1.156
storage temp.	2-8°C
form	powder to crystal
pka	11.72±0.29(Predicted)
color	White to Almost white

Safety information for 1,1-Bis(4-methoxyphenyl)-2-propyn-1-ol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.