11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
- CAS NO.：1977-07-7
- Empirical Formula: C18H20N4
- Molecular Weight: 292.38
- MDL number: MFCD01730958
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine?
Biological Activity
Deschloroclozapine is a potent, high-affinity, selective, metabolically stable agonist of muscarinic-based DREADDs.
in vitro
Deschloroclozapine has greater potencies for DREADDs than previous agonists in vitro. Deschloroclozapine is a potent agonist for hM 3 Dq with an EC 50 =0.13 nM. Deschloroclozapine is also a potent agonist for hM 4 Di with an EC 50 =0.081 nM.
Deschloroclozapine is a potent and selective agonist for hM 3 Dq and hM 4 Di, it does not display significant agonistic activity for any of the 318 tests wild-type GPCRs at <10 nM.
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storage
Room temperature
Properties of 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
| Boiling point: | 457.5±55.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO : ≥ 83.3 mg/mL (284.90 mM) |
| form | solid |
| pka | 7.82±0.20(Predicted) |
| color | Yellow |
Safety information for 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
Computed Descriptors for 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
New Products
Tetrabutylammonium hydrogen sulfate 2,2,6-Trimethyl-4H-1,3-dioxin-4-one 4-Piperidinopiperidine tert-Butyl acetoacetate 4-BROMOMETHYLTETRAHYDROPYRAN 3-Hydroxyazetidine hydrochloride Diallylamine, 99% Calcium hydroxide, 95% Aluminum oxide, basic 2-Bromophenylacetonitrile, 97% L-tert-Leucine,97% N-Hydroxy-2-methylpropanimidamide 4-(3,4-Dichlorophenyl)-3,4-Dihydro-N-Methyl-1-(2H)-Naphthalenimine (Schiff Base) 2-AMINO-3,5-DIBROMO BENZALDEHYDE [ADBA] L-Glutamic Acid Dimethyl Ester Hcl 10-Methoxy-5H-dibenz[b,f]azepine 5-Cyanophthalide N, N-Carbonyldiimidazole (CDI) 3-Methoxybenzonitrile 4-Methoxybenzonitrile Dibenzoyl Peroxide Titanium Dioxide Chloral PentachlorobenzonitrileRelated products of tetrahydrofuran
![(1S,3R,4S)-4-(2-((5-chloropyridin-
2-yl)amino)-2-oxoacetamido)-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexane-1-carboxylic acid](https://img.chemicalbook.in/CAS/20180629/GIF/834919-19-6.gif)
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