11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
- CAS NO.:1977-07-7
- Empirical Formula: C18H20N4
- Molecular Weight: 292.38
- MDL number: MFCD01730958
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-09 19:38:33
What is 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine?
Biological Activity
Deschloroclozapine is a potent, high-affinity, selective, metabolically stable agonist of muscarinic-based DREADDs.
in vitro
Deschloroclozapine has greater potencies for DREADDs than previous agonists in vitro. Deschloroclozapine is a potent agonist for hM 3 Dq with an EC 50 =0.13 nM. Deschloroclozapine is also a potent agonist for hM 4 Di with an EC 50 =0.081 nM.
Deschloroclozapine is a potent and selective agonist for hM 3 sub> Dq and hM 4 Di, it does not display significant agonistic activity for any of the 318 tests wild-type GPCRs at <10 nM.
b>
storage
Room temperature
Properties of 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
Boiling point: | 457.5±55.0 °C(Predicted) |
Density | 1.22±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | DMSO : ≥ 83.3 mg/mL (284.90 mM) |
form | solid |
pka | 7.82±0.20(Predicted) |
color | Yellow |
Safety information for 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
Computed Descriptors for 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
Lasmiditan Impurity 1
(1S,3R,4S)-4-(2-((5-chloropyridin-
2-yl)amino)-2-oxoacetamido)-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexane-1-carboxylic acid
Lasmiditan Impurity 6
Diacetonefructose
Lasmiditan Impurity 5
(6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone
(1-methylpiperidin-4-yl)(pyridin-2-yl)methanone
1-(((2S,3R)-2-(2,4-difluorophenyl)-3-Methyloxiran-2-yl)Methyl)-1H-1,2,4-triazole
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