11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
- CAS NO.：1977-07-7
- Empirical Formula: C18H20N4
- Molecular Weight: 292.38
- MDL number: MFCD01730958
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine?
Biological Activity
Deschloroclozapine is a potent, high-affinity, selective, metabolically stable agonist of muscarinic-based DREADDs.
in vitro
Deschloroclozapine has greater potencies for DREADDs than previous agonists in vitro. Deschloroclozapine is a potent agonist for hM 3 Dq with an EC 50 =0.13 nM. Deschloroclozapine is also a potent agonist for hM 4 Di with an EC 50 =0.081 nM.
Deschloroclozapine is a potent and selective agonist for hM 3 Dq and hM 4 Di, it does not display significant agonistic activity for any of the 318 tests wild-type GPCRs at <10 nM.
b>
storage
Room temperature
Properties of 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
| Boiling point: | 457.5±55.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO : ≥ 83.3 mg/mL (284.90 mM) |
| form | solid |
| pka | 7.82±0.20(Predicted) |
| color | Yellow |
Safety information for 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
Computed Descriptors for 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
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