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HomeProduct name list11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine Structural

What is 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine?

Biological Activity

Deschloroclozapine is a potent, high-affinity, selective, metabolically stable agonist of muscarinic-based DREADDs.

in vitro

Deschloroclozapine has greater potencies for DREADDs than previous agonists in vitro. Deschloroclozapine is a potent agonist for hM 3 Dq with an EC 50 =0.13 nM. Deschloroclozapine is also a potent agonist for hM 4 Di with an EC 50 =0.081 nM.
Deschloroclozapine is a potent and selective agonist for hM 3 Dq and hM 4 Di, it does not display significant agonistic activity for any of the 318 tests wild-type GPCRs at <10 nM.

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storage

Room temperature

Properties of 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

Boiling point: 457.5±55.0 °C(Predicted)
Density  1.22±0.1 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
solubility  DMSO : ≥ 83.3 mg/mL (284.90 mM)
form  solid
pka 7.82±0.20(Predicted)
color  Yellow

Safety information for 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

Computed Descriptors for 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine

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