11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
- CAS NO.：111974-74-4
- Empirical Formula: C17H18ClN3S
- Molecular Weight: 331.86
- MDL number: MFCD08703302
- EINECS: 1312995-182-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-22 11:53:02
![11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Structural](https://img.chemicalbook.in/CAS/GIF/111974-74-4.gif)
What is 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride?
Description
Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4
Chemical properties
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid
The Uses of 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic
The Uses of 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.
What are the applications of Application
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine
References
1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213 2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102 3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209 4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709
Properties of 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
| Melting point: | 180-184°C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO, Methanol, Distilled Water |
| form | solid |
| color | Off-white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H |
| CAS DataBase Reference | 111974-74-4(CAS DataBase Reference) |
Safety information for 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H413:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
| InChIKey | MJPARFLICDXWJT-UHFFFAOYSA-N |
| SMILES | C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl |
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