10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
Synonym(s):10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide;10,11-Dihydro-10-hydroxycarbamazepine;Licarbazepine
- CAS NO.：29331-92-8
- Empirical Formula: C15H14N2O2
- Molecular Weight: 254.28
- MDL number: MFCD00871817
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:58
What is 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE?
Chemical properties
White Solid
The Uses of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
A metabolite of Oxcarbazepine
The Uses of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
A labelled metabolite of Oxcarbazepine
The Uses of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
10,11-dihydro-10-hydroxy Carbamazepinee is the active metabolite of oxcarbazepine . Oxcarbazepine is rapidly and almost completely converted to 10,11-dihydro-10-hydroxycarbamazepine, which then demonstrates anticonvulsant efficacy by modulating several ion channels and receptors. ?10,11-dihydro-10-hydroxy Carbamazepine is reported to inhibit both voltage-gated Na+ and Ca2+ channels, to potentiate voltage-gated K+ channels, to antagonize adenosine A1 receptors, to increase dopaminergic transmission, and to inhibit glutamate release.
What are the applications of Application
10,11-Dihydro-10-hydroxy carbamazepine is a sodium channel protein inhibitor
Definition
ChEBI: A dibenzoazepine that is 5H-dibenzo[b,f]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel b ocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine.
storage
Store at RT
Properties of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
| Melting point: | 186-189°C |
| Boiling point: | 431.3±55.0 °C(Predicted) |
| Density | 1.336 |
| Flash point: | 2℃ |
| storage temp. | -20°C |
| solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| form | neat |
| pka | 13.75±0.20(Predicted) |
| form | Solid |
| color | White to off-white |
| BRN | 1540211 |
| CAS DataBase Reference | 29331-92-8 |
Safety information for 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
| Signal word | Danger |
| Pictogram(s) |
 Environment GHS09 |
| GHS Hazard Statements |
H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P501:Dispose of contents/container to..… |
Computed Descriptors for 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE
| InChIKey | BMPDWHIDQYTSHX-UHFFFAOYSA-N |
10,11-DIHYDRO-10-HYDROXYCARBAZEPINE manufacturer
ZCL Chemicals Ltd
Besil Chem LLP
Besil Chem LLP
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateYou may like
-
29331-92-8 Licarbazepine 99%View Details
29331-92-8 -
29331-92-8 98%View Details
29331-92-8 -
Licarbazepine 95.00% CAS 29331-92-8View Details
29331-92-8 -
Licarbazepine 98.00% CAS 29331-92-8View Details
29331-92-8 -
10,11-Dihydro-10-hydroxycarbamazepine CAS 29331-92-8View Details
29331-92-8 -
10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide 98%View Details
29331-92-8 -
Licarbazepine CAS 29331-92-8View Details
29331-92-8 -
10,11-Dihydro-10-Hydroxycarbamazepine solution CAS 29331-92-8View Details
29331-92-8