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HomeProduct name list10,11-DIHYDRO-10-HYDROXYCARBAZEPINE

10,11-DIHYDRO-10-HYDROXYCARBAZEPINE

Synonym(s):10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide;10,11-Dihydro-10-hydroxycarbamazepine;Licarbazepine

10,11-DIHYDRO-10-HYDROXYCARBAZEPINE Structural

What is 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE?

Chemical properties

White Solid

The Uses of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE

A metabolite of Oxcarbazepine

The Uses of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE

A labelled metabolite of Oxcarbazepine

The Uses of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE

10,11-dihydro-10-hydroxy Carbamazepinee is the active metabolite of oxcarbazepine . Oxcarbazepine is rapidly and almost completely converted to 10,11-dihydro-10-hydroxycarbamazepine, which then demonstrates anticonvulsant efficacy by modulating several ion channels and receptors. ?10,11-dihydro-10-hydroxy Carbamazepine is reported to inhibit both voltage-gated Na+ and Ca2+ channels, to potentiate voltage-gated K+ channels, to antagonize adenosine A1 receptors, to increase dopaminergic transmission, and to inhibit glutamate release.

What are the applications of Application

10,11-Dihydro-10-hydroxy carbamazepine is a sodium channel protein inhibitor

Definition

ChEBI: A dibenzoazepine that is 5H-dibenzo[b,f]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel b ocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine.

storage

Store at RT

Properties of 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE

Melting point: 186-189°C
Boiling point: 431.3±55.0 °C(Predicted)
Density  1.336
Flash point: 2℃
storage temp.  -20°C
solubility  Soluble to 100 mM in DMSO and to 50 mM in ethanol
form  neat
pka 13.75±0.20(Predicted)
form  Solid
color  White to off-white
BRN  1540211
CAS DataBase Reference 29331-92-8

Safety information for 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE

Signal word Danger
Pictogram(s)
ghs
Environment
GHS09
GHS Hazard Statements H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P273:Avoid release to the environment.
P391:Collect spillage. Hazardous to the aquatic environment
P501:Dispose of contents/container to..…

Computed Descriptors for 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE

InChIKey BMPDWHIDQYTSHX-UHFFFAOYSA-N

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