1-TRIMETHYLSILYLMETHANOL

Synonym(s):(Hydroxymethyl)trimethylsilane

CAS NO.：3219-63-4
Empirical Formula: C4H12OSi
Molecular Weight: 104.22
MDL number: MFCD00004596
EINECS: 221-746-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:35

What is 1-TRIMETHYLSILYLMETHANOL?

The Uses of 1-TRIMETHYLSILYLMETHANOL

1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent.

Purification Methods

If the NMR indicates impurities (should have only two signals), then dissolve it in Et2O, shake this with aqueous 5N NaOH, M H2SO4, saturated aqueous NaCl, dry (MgSO4) and distil it using an efficient column at atmospheric pressure. The 3,5-dinitrobenzoate has m 70-70.5o (from 95% EtOH). [Huang & Wang Acta Chem Sin 23 291 1957, cf. Chem Abstr 52 19911 1958, Speier et al. J Am Chem Soc 81 1844 1959 and Speier et al. J Am Chem Soc 70 1117 1948, Beilstein 4 III 1844, 4 IV 2876.]

Properties of 1-TRIMETHYLSILYLMETHANOL

Melting point:	<0°C
Boiling point:	120-122 °C754 mm Hg(lit.)
Density	0.826 g/mL at 25 °C(lit.)
refractive index	n20/D 1.419(lit.)
Flash point:	88 °F
storage temp.	2-8°C
form	clear liquid
pka	15.92±0.10(Predicted)
color	Colorless to Almost colorless
Specific Gravity	0.827
Water Solubility	Fully miscible in water.
Hydrolytic Sensitivity	1: no significant reaction with aqueous systems
BRN	1731486
CAS DataBase Reference	3219-63-4(CAS DataBase Reference)
EPA Substance Registry System	Methanol, (trimethylsilyl)- (3219-63-4)

Safety information for 1-TRIMETHYLSILYLMETHANOL

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.