1-(TRIISOPROPYLSILYL)PYRROLE

CAS NO.：87630-35-1
Empirical Formula: C13H25NSi
Molecular Weight: 223.43
MDL number: MFCD00054932
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 1-(TRIISOPROPYLSILYL)PYRROLE?

The Uses of 1-(TRIISOPROPYLSILYL)PYRROLE

1-(Triisopropylsilyl)pyrrole may be employed as reagent in perfluoroalkylation and Vilsmeier formylation reactions. It may be used in the preparation of ethyl 2-(2,4-dinitrophenylhydrazono]-3-[ 1-(triisopropylsily1)-pyrrol-2-yflpropanoate; heterocyclic base, 3-nitropyrrole and 3-nitropyrrole, required for the synthesis of 1 -(2?-deoxy-β-D-ribofuranosyl)-3-nitropyrrole. It participates in various electrophilic substitution reactions specifically at β-position, via reaction with various electrophilic reagents (Br+, I+,NO2+,etc).

The Uses of 1-(TRIISOPROPYLSILYL)PYRROLE

1-(Triisopropylsilyl)pyrrole may be employed as reagent in perfluoroalkylation and Vilsmeier formylation reactions. It may be used in the preparation of:

ethyl 2-(2,4-dinitrophenylhydrazono]-3-[ 1-(triisopropylsily1)-pyrrol-2-yflpropanoate
heterocyclic base, 3-nitropyrrole
3-nitropyrrole, required for the synthesis of 1 -(2′-deoxy-β-D-ribofuranosyl)-3-nitropyrrole

What are the applications of Application

1-(Triisopropylsilyl)pyrrole is a reagent used in perfluoroalkylation and vilsmeter formylation reactions

General Description

1-(Triisopropylsilyl)pyrrole (TISP), a heterocyclic building block, is a pyrrole derivative. TISP has been reported to generate pyrrolic cation radicals during cyclovoltammetric studies, via electroreduction. It participates in various electrophilic substitution reactions specifically at β-position, via reaction with various electrophilic reagents (Br⁺, I⁺,NO₂⁺,etc).

Properties of 1-(TRIISOPROPYLSILYL)PYRROLE

Boiling point:	78 °C0.4 mm Hg(lit.)
Density	0.904 g/mL at 25 °C(lit.)
refractive index	n20/D 1.492(lit.)
Flash point:	224 °F
storage temp.	Inert atmosphere,2-8°C
form	clear liquid
pka	-2.55±0.70(Predicted)
Specific Gravity	0.904
color	Colorless to Almost colorless
Water Solubility	Not miscible in water.
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	7: reacts slowly with moisture/water
BRN	3540663
CAS DataBase Reference	87630-35-1(CAS DataBase Reference)

Safety information for 1-(TRIISOPROPYLSILYL)PYRROLE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.