1-METHYLHYDANTOIN
Synonym(s):1-Methylimidazolidine-2,4-dione;Dioxy-creatinine;NSC 80560
- CAS NO.：616-04-6
- Empirical Formula: C4H6N2O2
- Molecular Weight: 114.1
- MDL number: MFCD00003187
- EINECS: 210-460-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:11
What is 1-METHYLHYDANTOIN?
Chemical properties
WHITE FINE CRYSTALLINE POWDER
The Uses of 1-METHYLHYDANTOIN
Reactant for organocatalytic tandem three component reactions of aldehyde, alkyl vinyl ketone, and amide
Reactant for synthesis of:
- Selective angiotensin II AT2 receptor agonists with reduced CYP 450 inhibition
- Allosteric glucokinase activators
- Hydantoin derivatives with antiproliferative activity
- Thiohydantoins
- P2X7 receptor antagonists
What are the applications of Application
1-Methylhydantoin is a useful intermediate
Definition
ChEBI: A imidazolidine-2,4-dione that is the N-methyl-derivative of hydantoin.
Metabolic pathway
The metabolic pathway of 1-methylhydantoin via 5-hydroxy-1-methylhydantoin, methylparabanic acid, and 5-N-methyloxaluric acid proves to be a major and general metabolic pathway in rabbits.
Properties of 1-METHYLHYDANTOIN
| Melting point: | 156-157 °C(lit.) |
| Boiling point: | 213.59°C (rough estimate) |
| Density | 1.284 |
| refractive index | 1.4487 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.94±0.10(Predicted) |
| color | White to Off-White |
| Water Solubility | Soluble in methanol. (almost transparency). Insoluble in water. |
| CAS DataBase Reference | 616-04-6(CAS DataBase Reference) |
Safety information for 1-METHYLHYDANTOIN
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-METHYLHYDANTOIN
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin M Tubulysin B (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 2,2-diethoxyethanethioamide Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-N-BOC-(S)-AMINO BUTYRONITRILE 3-Aminocyclobutanone hydrochloride 4-(Benzyloxy)-3-bromophenylacetic Acid 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 2,2-Difluoropropylamine hydrochloride Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
![1-[(2,6-DICHLORO-4-METHYL-3-PYRIDYL)CARBONYL]-3-(2,5-DICHLOROPHENYL)IMIDAZOLIDINE-2,4,5-TRIONE](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB4356668.gif)
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