1-METHYLHYDANTOIN
Synonym(s):1-Methylimidazolidine-2,4-dione;Dioxy-creatinine;NSC 80560
- CAS NO.：616-04-6
- Empirical Formula: C4H6N2O2
- Molecular Weight: 114.1
- MDL number: MFCD00003187
- EINECS: 210-460-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-11 17:44:06
What is 1-METHYLHYDANTOIN?
Chemical properties
WHITE FINE CRYSTALLINE POWDER
The Uses of 1-METHYLHYDANTOIN
Reactant for organocatalytic tandem three component reactions of aldehyde, alkyl vinyl ketone, and amide
Reactant for synthesis of:
- Selective angiotensin II AT2 receptor agonists with reduced CYP 450 inhibition
- Allosteric glucokinase activators
- Hydantoin derivatives with antiproliferative activity
- Thiohydantoins
- P2X7 receptor antagonists
What are the applications of Application
1-Methylhydantoin is a useful intermediate
Definition
ChEBI: A imidazolidine-2,4-dione that is the N-methyl-derivative of hydantoin.
Metabolic pathway
The metabolic pathway of 1-methylhydantoin via 5-hydroxy-1-methylhydantoin, methylparabanic acid, and 5-N-methyloxaluric acid proves to be a major and general metabolic pathway in rabbits.
Properties of 1-METHYLHYDANTOIN
| Melting point: | 156-157 °C(lit.) |
| Boiling point: | 213.59°C (rough estimate) |
| Density | 1.284 |
| refractive index | 1.4487 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.94±0.10(Predicted) |
| color | White to Off-White |
| Water Solubility | Soluble in methanol. (almost transparency). Insoluble in water. |
| CAS DataBase Reference | 616-04-6(CAS DataBase Reference) |
Safety information for 1-METHYLHYDANTOIN
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-METHYLHYDANTOIN
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