1-Methyl-2-phenylindole

Synonym(s):NSC 63793

CAS NO.：3558-24-5
Empirical Formula: C15H13N
Molecular Weight: 207.27
MDL number: MFCD00022892
EINECS: 222-618-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-03-27 14:23:02

What is 1-Methyl-2-phenylindole?

Chemical properties

WHITE TO LIGHT GREEN-TAN CRYSTALS OR CRYST. POWDER

The Uses of 1-Methyl-2-phenylindole

Reactant for preparation of:

Cyano indoles
Difluorohydroxy indoles

Reactant for:

Carboxylation of indoles
Allylation of indoles
Formylation of indoles
Nitrosylation of indoles

What are the applications of Application

1-Methyl-2-phenylindole is a chromophore intermediate

Synthesis Reference(s)

Tetrahedron Letters, 34, p. 2059, 1993 DOI: 10.1016/S0040-4039(00)60345-3

General Description

Reaction of 1-methyl-2-phenylindole with nitrogen dioxide or with nitrous acid (NaNO₂-CH₃COOH) in benzene has been studied. 1-Methyl-2-phenylindole is reported to react with malondialdehyde (MDA) and 4-hydroxyalkenals to afford a stable chromophore with intense maximal absorbance at 586nm.

Properties of 1-Methyl-2-phenylindole

Melting point:	98-100 °C (lit.)
Boiling point:	336.3°C (rough estimate)
Density	1.0880 (rough estimate)
refractive index	1.5720 (estimate)
storage temp.	2-8°C
form	powder to crystal
color	White to Light yellow
BRN	148770
InChI	InChI=1S/C15H13N/c1-16-14-10-6-5-9-13(14)11-15(16)12-7-3-2-4-8-12/h2-11H,1H3
CAS DataBase Reference	3558-24-5(CAS DataBase Reference)
EPA Substance Registry System	1H-Indole, 1-methyl-2-phenyl- (3558-24-5)

Safety information for 1-Methyl-2-phenylindole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.