4-Ethoxy-2,3-difluorophenol
- CAS NO.：126163-56-2
- Empirical Formula: C8H8F2O2
- Molecular Weight: 174.14
- MDL number: MFCD07368025
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-25 13:42:50
What is 4-Ethoxy-2,3-difluorophenol?
Chemical properties
white solid
Synthesis
In a 1 L four-reaction vessel, 326.7 g of tetrahydrofuran and 132.9 g of glacial acetic acid were added, stirred for 30 min,Adding 110.0g 2.3-difluoro-4-ethoxybenzeneboronic acid crude, stirring for half an hour, the control temperature between 15 ~ 25 ° C,Dropping 111. 1 g of hydrogen peroxide, stirring was added dropwise insulation lh, sample testing, raw material residue 0.15%To the vessel was added water 200.0g and 15. lg sodium sulfite treatment, stratification, the upper organic phase rejection rate was 2.3-difluoro-4-ethoxy phenol crude 85.0g, distilled product 64.8g, GC purity: 99 ? 96 %, Two-step yield 69 ? 8%
Properties of 4-Ethoxy-2,3-difluorophenol
| Melting point: | 73℃ |
| Boiling point: | 235℃ |
| Density | 1.273 |
| Flash point: | 116℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 8.26±0.23(Predicted) |
Safety information for 4-Ethoxy-2,3-difluorophenol
| Signal word | Warning |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4-Ethoxy-2,3-difluorophenol
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