1-CHLORO-3-METHOXY-2-PROPANOL

Synonym(s):3-Chloro-1-methoxy-2-propanol

CAS NO.：4151-97-7
Empirical Formula: C4H9ClO2
Molecular Weight: 124.57
MDL number: MFCD00018935
EINECS: 223-982-4
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

1-CHLORO-3-METHOXY-2-PROPANOL Structural

What is 1-CHLORO-3-METHOXY-2-PROPANOL?

Chemical properties

Clear faintly yellow oily liquid

The Uses of 1-CHLORO-3-METHOXY-2-PROPANOL

1-Chloro-3-methoxy-2-propanol is used in the synthesis of O-Methylganciclovir (M275440), an analogue of Ganciclovir (G235000) and displays excellent antiviral activity when tested in vivo against herpes simplex virus type 1 infection in mice.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 275, 1988 DOI: 10.1021/jo00237a009
Synthetic Communications, 24, p. 1959, 1994 DOI: 10.1080/00397919408010203

Properties of 1-CHLORO-3-METHOXY-2-PROPANOL

Boiling point:	171°C
Density	1,161 g/cm³
refractive index	1.4463
Flash point:	72°C
storage temp.	Store below +30°C.
solubility	Chloroform, DMSO (Sparingly), Methanol (Slightly)
form	Oily Liquid
pka	13.28±0.20(Predicted)
color	Clear faintly yellow
PH	5.6 (50g/l, H2O)
BRN	1697491

Safety information for 1-CHLORO-3-METHOXY-2-PROPANOL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.