1-Butanesulfonyl chloride

CAS NO.：2386-60-9
Empirical Formula: C4H9ClO2S
Molecular Weight: 156.63
MDL number: MFCD00007464
EINECS: 219-204-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-06 17:55:34

What is 1-Butanesulfonyl chloride?

Description

1-Butanesulfonyl chloride is an antimicrobial agent that inhibits the production of inflammatory substances. It has been shown to inhibit acetylcholinesterase activity and the growth of cancer cells in vitro. 1-Butanesulfonyl chloride is a cross-linking agent that can be used to produce amides, which are used as pharmaceutical preparations for treating inflammatory diseases.

Chemical properties

clear colourless to light yellow liquid

The Uses of 1-Butanesulfonyl chloride

1-Butanesulfonyl chloride has been used in the preparation of:

ethyl 2-(1-butanesulfonamido)pent-4-yn-l-oate
1-butanesulfonamid-N,N′-1,2-ethanediylbis
1-butanesulfonamide-N,N′-1,3-propanediylbis

Purification Methods

It has a pungent odour and is LACHRYMATORY. If IR shows OH bands, then dissolve in Et2O, wash with cold saturated aqueous NaHCO3 (care since CO2 will be generated) then H2O, dry it over solid Na2SO4, filter, evaporate and distil the residue twice. Characterise it by shaking a solution in Et2O or *C6H6 with aqueous NH3, collect the solid 1-butanesulfonamide with m 48o after recrystallisation from CHCl3, CCl4 or Et2O/pet ether. [Douglass & Johnson J Am Chem Soc 60 1488 1938, Lee & Dougherty J Org Chem 5 83 1940, Beilstein 4 IV 45.]

Properties of 1-Butanesulfonyl chloride

Melting point:	-29°C
Boiling point:	80-81 °C/9 mmHg (lit.)
Density	1.208 g/mL at 25 °C (lit.)
vapor pressure	0.5 mm Hg ( 20 °C)
refractive index	n20/D 1.454(lit.)
Flash point:	175 °F
form	Liquid
color	Clear colorless to light yellow or light orange
Water Solubility	DECOMPOSES
Sensitive	Moisture Sensitive
BRN	1748742
CAS DataBase Reference	2386-60-9(CAS DataBase Reference)
NIST Chemistry Reference	1-Butanesulfonyl chloride(2386-60-9)
EPA Substance Registry System	1-Butanesulfonyl chloride (2386-60-9)

Safety information for 1-Butanesulfonyl chloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H227:Flammable liquids H290:Corrosive to Metals H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H341:Germ cell mutagenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P390:Absorb spillage to prevent material damage. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..…