1-Butanesulfonyl chloride
- CAS NO.：2386-60-9
- Empirical Formula: C4H9ClO2S
- Molecular Weight: 156.63
- MDL number: MFCD00007464
- EINECS: 219-204-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 13:31:19
What is 1-Butanesulfonyl chloride?
Description
1-Butanesulfonyl chloride is an antimicrobial agent that inhibits the production of inflammatory substances. It has been shown to inhibit acetylcholinesterase activity and the growth of cancer cells in vitro. 1-Butanesulfonyl chloride is a cross-linking agent that can be used to produce amides, which are used as pharmaceutical preparations for treating inflammatory diseases.
Chemical properties
clear colourless to light yellow liquid
The Uses of 1-Butanesulfonyl chloride
1-Butanesulfonyl chloride has been used in the preparation of:
- ethyl 2-(1-butanesulfonamido)pent-4-yn-l-oate
- 1-butanesulfonamid-N,N′-1,2-ethanediylbis
- 1-butanesulfonamide-N,N′-1,3-propanediylbis
Purification Methods
It has a pungent odour and is LACHRYMATORY. If IR shows OH bands, then dissolve in Et2O, wash with cold saturated aqueous NaHCO3 (care since CO2 will be generated) then H2O, dry it over solid Na2SO4, filter, evaporate and distil the residue twice. Characterise it by shaking a solution in Et2O or *C6H6 with aqueous NH3, collect the solid 1-butanesulfonamide with m 48o after recrystallisation from CHCl3, CCl4 or Et2O/pet ether. [Douglass & Johnson J Am Chem Soc 60 1488 1938, Lee & Dougherty J Org Chem 5 83 1940, Beilstein 4 IV 45.]
Properties of 1-Butanesulfonyl chloride
| Melting point: | -29°C |
| Boiling point: | 80-81 °C/9 mmHg (lit.) |
| Density | 1.208 g/mL at 25 °C (lit.) |
| vapor pressure | 0.5 mm Hg ( 20 °C) |
| refractive index | n |
| Flash point: | 175 °F |
| form | Liquid |
| color | Clear colorless to light yellow or light orange |
| Water Solubility | DECOMPOSES |
| Sensitive | Moisture Sensitive |
| BRN | 1748742 |
| CAS DataBase Reference | 2386-60-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Butanesulfonyl chloride(2386-60-9) |
| EPA Substance Registry System | 1-Butanesulfonyl chloride (2386-60-9) |
Safety information for 1-Butanesulfonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H227:Flammable liquids H290:Corrosive to Metals H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H341:Germ cell mutagenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P390:Absorb spillage to prevent material damage. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..… |
Computed Descriptors for 1-Butanesulfonyl chloride
| InChIKey | WEDIIKBPDQQQJU-UHFFFAOYSA-N |
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