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HomeProduct name list1-Bromodibenzothiophene

1-Bromodibenzothiophene

1-Bromodibenzothiophene Structural

What is 1-Bromodibenzothiophene?

The Uses of 1-Bromodibenzothiophene

1-Bromodibenzothiophene can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

Synthesis_65642-94-6
Into a 1 L four-necked round bottom flask equipped with a stirrer, a Liebig condenser (not required), a 100 mL dropping funnel and a thermometer, 43.5 g (0.156 mol) of the amine hydrochloride obtained in the above ), 240 mL of acetic acid, 55 mL of concentrated hydrochloric acid and 143 mL of water were placed and cooled to -5 ?? C. or lower in an ice water bath. Next, an aqueous solution of 12.0 g (0.173 mol) of sodium nitrite dissolved in 67 mL of water was added dropwise from the dropping funnel at a temperature not exceeding 5 ?? C., and the mixture was stirred at 5 ?? C. or less for 1 hour.The resulting diazo solution was transferred to a 1 L dropping funnel and set in a 1 L 4-necked round bottom flask equipped with a stirrer, a Liebig condenser (not required) and a thermometer, and then 50 % Hypophosphorous acid and 90 mL of water were added, and the mixture was cooled to -5 ?? C. or lower in an ice water bath. Subsequently, the diazo solution was added dropwise at a temperature not exceeding 5 ?? C., after stirring for 1 hour in an ice water bath, it was returned to room temperature and stirred at room temperature for 48 hours.The obtained reaction solution was extracted twice with 310 mL of ethyl acetate, then washed twice with 310 mL of water, dried with magnesium sulfate, magnesium sulfate was removed by suction filtration, and the solvent was distilled off under reduced pressure. Subsequently, the obtained crude oil was purified on a silica gel column using n-heptane as a developing solution to obtain 33.8 g (yield: 82.5%) of the desired bromide.

Properties of 1-Bromodibenzothiophene

Melting point: 84 °C
Boiling point: 386.6±15.0 °C(Predicted)
Density  1.611±0.06 g/cm3(Predicted)
form  powder to crystal
color  White to Orange to Green

Safety information for 1-Bromodibenzothiophene

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H227:Flammable liquids
H314:Skin corrosion/irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P310:Immediately call a POISON CENTER or doctor/physician.
P363:Wash contaminated clothing before reuse.
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378:In case of fire: Use … for extinction.
P405:Store locked up.
P403+P235:Store in a well-ventilated place. Keep cool.
P501:Dispose of contents/container to..…

Computed Descriptors for 1-Bromodibenzothiophene

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