1-Bromo-3-phenylpropane

Synonym(s):(3-Bromopropyl)benzene;3-Phenylpropyl bromide;Hydrocinnamyl bromide

CAS NO.：637-59-2
Empirical Formula: C9H11Br
Molecular Weight: 199.09
MDL number: MFCD00000257
EINECS: 211-294-7
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 1-Bromo-3-phenylpropane?

Chemical properties

Colorless to light yellow liqui

The Uses of 1-Bromo-3-phenylpropane

1-Bromo-3-phenylpropane is used in the synthesis of MraY natural inhibitors as antibacterial agents. Also used in the preparation of quinolinone derivatives as potent and selective MAO-B inhibitors.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 31, p. 4189, 1983 DOI: 10.1248/cpb.31.4189

Purification Methods

Wash the bromide successively with conc H2SO4, water, 10% aqueous Na2CO3 and again with water, then dry it with CaCl2 and fractionally distil it just before use. [Beilstein 5 IV 982.]

Properties of 1-Bromo-3-phenylpropane

Melting point:	-10°C (estimate)
Boiling point:	237-238 °C (lit.)
Density	1.31 g/mL at 25 °C (lit.)
refractive index	n20/D 1.546(lit.)
Flash point:	215 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Methanol
form	Liquid
color	Clear colorless to light yellow
Specific Gravity	1.31
Water Solubility	INSOLUBLE
BRN	2205527
CAS DataBase Reference	637-59-2(CAS DataBase Reference)
NIST Chemistry Reference	1-Bromo-3-phenylpropane(637-59-2)
EPA Substance Registry System	(3-Bromopropyl)benzene (637-59-2)

Safety information for 1-Bromo-3-phenylpropane

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.