1-Bromo-2-(2-methoxyethoxy)ethane
- CAS NO.:54149-17-6
- Empirical Formula: C5H11BrO2
- Molecular Weight: 183.04
- MDL number: MFCD00000238
- EINECS: 259-000-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-11-10 16:48:32
What is 1-Bromo-2-(2-methoxyethoxy)ethane?
Chemical properties
clear colorless to pale yellow liquid
The Uses of 1-Bromo-2-(2-methoxyethoxy)ethane
1-Bromo-2-(2-methoxyethoxy)ethane is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
General Procedure for Preparation of 1-Bromo-2-(2-methoxyethoxy)ethane: Into a 25-mL round bottomed flask equipped with magnetic stir bar, addition funnel and positive flow of nitrogen were placed 15.60 mmol of a ethyleneglycol monomethyl ether. The solution was stirred for 15 min in an ice bath before the dropwise addition of phosphorous tribromide (7.81 mmol) over a 10 min period. The solution was allowed to gradually warm and stir at room temperature (rt) for 14 hrs. The solution was then heated in a 90 °C oil bath for 1 hr, at which time the solution turned yellow. The solution was allowed to cool to rt, poured onto 30 g of ice/water mixture, and made slightly basic with addition of a 10% solution of NaHCO3 (~6 mL). Subsequent extraction with diethyl ether (Et2O) (3 x 30 mL), followed by drying over MgSO4 and concentration under reduced pressure afforded a colorless oil in sufficient purity for use in subsequent reactions.
Properties of 1-Bromo-2-(2-methoxyethoxy)ethane
Boiling point: | 156 °C (lit.)
37-40 °C/0.01 mmHg (lit.) |
Density | 1.3600 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 163 °F |
storage temp. | 2-8°C |
form | Liquid |
color | Clear colorless to pale yellow |
Water Solubility | Not miscible in water. |
Sensitive | Light Sensitive |
BRN | 2069579 |
InChI | InChI=1S/C5H11BrO2/c1-7-4-5-8-3-2-6/h2-5H2,1H3 |
CAS DataBase Reference | 54149-17-6(CAS DataBase Reference) |
NIST Chemistry Reference | 1-Bromo-2-(2-methoxyethoxy)ethane(54149-17-6) |
Safety information for 1-Bromo-2-(2-methoxyethoxy)ethane
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids |
Precautionary Statement Codes |
P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for 1-Bromo-2-(2-methoxyethoxy)ethane
InChIKey | HUXJXNSHCKHFIL-UHFFFAOYSA-N |
SMILES | C(OCCBr)COC |
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