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HomeProduct name list1-BENZYLPIPERIDINE-4-CARBONITRILE

1-BENZYLPIPERIDINE-4-CARBONITRILE

1-BENZYLPIPERIDINE-4-CARBONITRILE Structural

What is 1-BENZYLPIPERIDINE-4-CARBONITRILE?

The Uses of 1-BENZYLPIPERIDINE-4-CARBONITRILE

1-Benzylpiperidine-4-carbonitrile is an intermediate in organic synthesis and pharmaceutical intermediate for lab R&D.

Synthesis

Synthetic route of 1-benzyl-4-cyanopiperidine

Step 1 Preparation of intermediate 1-benzyl-4-carbonylamide piperidine

To piperidine-4-carboxamide (16.5 g, 0.13 mol ) and K2CO3 (35.6 g, 0.26 mol) in EtOH (350 ml) was added benzyl bromide (22.0 g, 0.13 mol) And heated to reflux for 3 h, cooled to room temperature and filtered. The filtrate was evaporated in vacuo and H2O (200ml) was added. The aqueous layer was extracted with CH2Cl2 (3×150ml), the organic layers were combined, and Na2SO4Dry and filter. The solvent was evaporated in vacuo to give the product as a white solid (20.0 g, 71.0%).

Step 2 Preparation of intermediate 1-benzyl-4-cyanopiperidine

1-benzyl-4-carbonylamide piperidine (20.0 g, 91.7 mmol) Mixed with P2O5 (16.92, 119.2 mmol) and heated under argon at 180-200°C for 3 h, cooled to room temperature and added H2O (150 ml). The aqueous solution was basified by the careful addition of K2CO3 and then extracted with EtOAc (3× 150 ml). The organic extract was dried over Na2SO4, filtered and the solvent evaporated in vacuo to give a yellow oil (16.7 g, 90.9%).

Properties of 1-BENZYLPIPERIDINE-4-CARBONITRILE

Boiling point: 330.3±35.0 °C(Predicted)
Density  1.06
storage temp.  2-8°C
pka 6.95±0.10(Predicted)

Safety information for 1-BENZYLPIPERIDINE-4-CARBONITRILE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 1-BENZYLPIPERIDINE-4-CARBONITRILE

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