1-(6-nitropyridin-3-yl)piperazine
- CAS NO.：775288-71-6
- Empirical Formula: C9H12N4O2
- Molecular Weight: 208.22
- MDL number: MFCD09041112
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 1-(6-nitropyridin-3-yl)piperazine?
The Uses of 1-(6-nitropyridin-3-yl)piperazine
1-?(6-?Nitro-?3-?pyridinyl)?piperazine is a reagent used in the preparation of highly potent and orally bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine cyclin-dependant kinases as anticancer agents. Also is an impurity of Palbociclib (P139900), an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
Properties of 1-(6-nitropyridin-3-yl)piperazine
| Boiling point: | 422.8±40.0 °C(Predicted) |
| Density | 1.278±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform; Methanol |
| form | Solid |
| pka | 8.50±0.10(Predicted) |
| color | Yellow |
Safety information for 1-(6-nitropyridin-3-yl)piperazine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(6-nitropyridin-3-yl)piperazine
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