1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
Synonym(s):1-((4-Chlorobenzyl)-1H-indole-3-carboxaldehyde, Oncogenic Ras Tumor- Inhibiting compound 1;1-((4-Chlorobenzyl)-1H-indole-3-carboxaldehyde, Oncogenic Ras Tumor-Inhibiting compound 1;1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde;Oncrasin-1 - CAS 75629-57-1 - Calbiochem
- CAS NO.：75629-57-1
- Empirical Formula: C16H12ClNO
- Molecular Weight: 269.73
- MDL number: MFCD01051808
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE?
The Uses of 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
Oncrasin 1 is a proapoptotic compound.
What are the applications of Application
Oncrasin 1 is a proapoptotic compound
Definition
ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.
Biological Activity
Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .
storage
+4°C
Properties of 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
| Melting point: | 115.0 to 119.0 °C |
| Boiling point: | 465.5±30.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | off-white to light tan |
| Sensitive | Light Sensitive |
Safety information for 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
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