1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
Synonym(s):1-((4-Chlorobenzyl)-1H-indole-3-carboxaldehyde, Oncogenic Ras Tumor- Inhibiting compound 1;1-((4-Chlorobenzyl)-1H-indole-3-carboxaldehyde, Oncogenic Ras Tumor-Inhibiting compound 1;1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde;Oncrasin-1 - CAS 75629-57-1 - Calbiochem
- CAS NO.：75629-57-1
- Empirical Formula: C16H12ClNO
- Molecular Weight: 269.73
- MDL number: MFCD01051808
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE?
The Uses of 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
Oncrasin 1 is a proapoptotic compound.
What are the applications of Application
Oncrasin 1 is a proapoptotic compound
Definition
ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.
Biological Activity
Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .
storage
+4°C
Properties of 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
| Melting point: | 115.0 to 119.0 °C |
| Boiling point: | 465.5±30.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | off-white to light tan |
| Sensitive | Light Sensitive |
Safety information for 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
New Products
2,2-diethoxyethanethioamide Tubulysin C Tubulysin B 4,4-DIFLUOROPIPERIDINE 1-(1,1-Difluoroethyl)-2-fluorobenzene 2H-Pyran, 4-ethynyltetrahydro- 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 3-Aminocyclobutanone hydrochloride 2,2-Difluoropropanol Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
![1-[1-(4-CHLOROBENZOYL)-1H-INDOL-3-YL]-1-ETHANONE](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB9352160.gif)
You may like
-
Oncrasin 1 CAS 75629-57-1View Details
75629-57-1 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.