1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

Synonym(s):TRIM

CAS NO.：25371-96-4
Empirical Formula: C10H7F3N2
Molecular Weight: 212.17
MDL number: MFCD00041206
EINECS: 636-734-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-09 21:40:10

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Structural

What is 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE?

Description

TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50?= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1?TRIM displays antinociceptive activity?in vivo.2

The Uses of 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

TRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models.

What are the applications of Application

TRIM is a NOS1 (nNOS) and NOS2 (iNOS) inhibitor

Definition

ChEBI: 1-[2-(trifluoromethyl)phenyl]imidazole is a member of imidazoles.

Biological Activity

A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo .

Biochem/physiol Actions

Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.

References

1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349 2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423

Properties of 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

Melting point:	43 °C
Boiling point:	75°C 0,02mm
Density	1.3253 (estimate)
Flash point:	75°C/0.025mm
storage temp.	2-8°C
solubility	Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).
form	White solid.
pka	4.96±0.10(Predicted)
color	White
Sensitive	Light Sensitive
BRN	3955637
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference	25371-96-4(CAS DataBase Reference)

Safety information for 1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.