1-(2-Methoxyphenyl)piperazine

CAS NO.：35386-24-4
Empirical Formula: C11H16N2O
Molecular Weight: 192.26
MDL number: MFCD00005958
EINECS: 252-537-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:17

What is 1-(2-Methoxyphenyl)piperazine?

Chemical properties

clear colorless to yellow liquid after melting

The Uses of 1-(2-Methoxyphenyl)piperazine

1-(2-Methoxyphenyl)piperazine can be used:

To functionalize pyrazolylvinyl ketones via Aza-Michael addition reaction.
To prepare cyclic amine substituted Tr?ger′s base derivatives.
To prepare functionalized bis(mercaptoimidazolyl)borates by reacting with the activated ester, [(1-methyl-2-mercaptoimidazol-5-yl)carbonyl]succinimide.

The Uses of 1-(2-Methoxyphenyl)piperazine

A piperazine derivative and a selective antagonist at D3 receptors that influences the expression of cocaine-induced conditioned place preference (CPP).

The Uses of 1-(2-Methoxyphenyl)piperazine

It is used as pharmaceutical intermediate. N-alkylated 1-(2-methyoxyphenyl)piperazines markedly improved affinity and selectivity of the dopamine D3 receptor which is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders.

Definition

ChEBI: 1-(2-methoxyphenyl)piperazine is a member of piperazines.

Properties of 1-(2-Methoxyphenyl)piperazine

Melting point:	35-40 °C (lit.)
Boiling point:	130-133 °C/0.1 mmHg (lit.)
Density	1.095 g/mL at 25 °C (lit.)
refractive index	n20/D 1.575(lit.)
Flash point:	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Liquid After Melting
pka	8.98±0.10(Predicted)
color	Clear colorless to yellow
Water Solubility	Soluble in chloroform, ethyl acetate, and methanol. Insoluble in water
Sensitive	Air Sensitive
BRN	167888
InChI	InChI=1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3
CAS DataBase Reference	35386-24-4(CAS DataBase Reference)

Safety information for 1-(2-Methoxyphenyl)piperazine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.