1-(2-Methoxyphenyl)piperazine
- CAS NO.：35386-24-4
- Empirical Formula: C11H16N2O
- Molecular Weight: 192.26
- MDL number: MFCD00005958
- EINECS: 252-537-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:17
What is 1-(2-Methoxyphenyl)piperazine?
Chemical properties
clear colorless to yellow liquid after melting
The Uses of 1-(2-Methoxyphenyl)piperazine
1-(2-Methoxyphenyl)piperazine can be used:
- To functionalize pyrazolylvinyl ketones via Aza-Michael addition reaction.
- To prepare cyclic amine substituted Tr?ger′s base derivatives.
- To prepare functionalized bis(mercaptoimidazolyl)borates by reacting with the activated ester, [(1-methyl-2-mercaptoimidazol-5-yl)carbonyl]succinimide.
The Uses of 1-(2-Methoxyphenyl)piperazine
A piperazine derivative and a selective antagonist at D3 receptors that influences the expression of cocaine-induced conditioned place preference (CPP).
The Uses of 1-(2-Methoxyphenyl)piperazine
It is used as pharmaceutical intermediate. N-alkylated 1-(2-methyoxyphenyl)piperazines markedly improved affinity and selectivity of the dopamine D3 receptor which is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders.
Definition
ChEBI: 1-(2-methoxyphenyl)piperazine is a member of piperazines.
Properties of 1-(2-Methoxyphenyl)piperazine
| Melting point: | 35-40 °C (lit.) |
| Boiling point: | 130-133 °C/0.1 mmHg (lit.) |
| Density | 1.095 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Liquid After Melting |
| pka | 8.98±0.10(Predicted) |
| color | Clear colorless to yellow |
| Water Solubility | Soluble in chloroform, ethyl acetate, and methanol. Insoluble in water |
| Sensitive | Air Sensitive |
| BRN | 167888 |
| InChI | InChI=1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3 |
| CAS DataBase Reference | 35386-24-4(CAS DataBase Reference) |
Safety information for 1-(2-Methoxyphenyl)piperazine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(2-Methoxyphenyl)piperazine
| InChIKey | VNZLQLYBRIOLFZ-UHFFFAOYSA-N |
| SMILES | N1(C2=CC=CC=C2OC)CCNCC1 |
1-(2-Methoxyphenyl)piperazine manufacturer
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